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Role of liver sinusoidal endothelial cells in liver diseases
Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike
other capillaries, they lack an organized basement membrane and have cytoplasm that is …
other capillaries, they lack an organized basement membrane and have cytoplasm that is …
Mechanical communication in fibrosis progression
Mechanical hallmarks of fibrotic microenvironments are both outcomes and causes of
fibrosis progression. Understanding how cells sense and transmit mechanical cues in the …
fibrosis progression. Understanding how cells sense and transmit mechanical cues in the …
Kupffer cell–like syncytia replenish resident macrophage function in the fibrotic liver
Kupffer cells (KCs) are localized in liver sinusoids but extend pseudopods to parenchymal
cells to maintain their identity and serve as the body's central bacterial filter. Liver cirrhosis …
cells to maintain their identity and serve as the body's central bacterial filter. Liver cirrhosis …
Role of liver sinusoidal endothelial cells in non-alcoholic fatty liver disease
A Hammoutene, PE Rautou - Journal of hepatology, 2019 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) and its complications are an expanding health
problem associated with the metabolic syndrome. Liver sinusoidal endothelial cells (LSECs) …
problem associated with the metabolic syndrome. Liver sinusoidal endothelial cells (LSECs) …
Pathophysiology of decompensated cirrhosis: portal hypertension, circulatory dysfunction, inflammation, metabolism and mitochondrial dysfunction
Patients with acutely decompensated cirrhosis have a dismal prognosis and frequently
progress to acute-on-chronic liver failure, which is characterised by hepatic and extrahepatic …
progress to acute-on-chronic liver failure, which is characterised by hepatic and extrahepatic …
Cell senescence in liver diseases: pathological mechanism and theranostic opportunity
The liver is not oblivious to the passage of time, as ageing is a major risk factor for the
development of acute and chronic liver diseases. Ageing produces alterations in all hepatic …
development of acute and chronic liver diseases. Ageing produces alterations in all hepatic …
[HTML][HTML] Pan-PPAR agonist lanifibranor improves portal hypertension and hepatic fibrosis in experimental advanced chronic liver disease
Background & aims In advanced chronic liver disease (ACLD), deregulated hepatic
necroinflammatory processes play a key role in the development of liver microvascular …
necroinflammatory processes play a key role in the development of liver microvascular …
Sequential nano-penetrators of capillarized liver sinusoids and extracellular matrix barriers for liver fibrosis therapy
LF Zhang, XH Wang, CL Zhang, J Lee, BW Duan… - ACS …, 2022 - ACS Publications
During liver fibrogenesis, liver sinusoidal capillarization and extracellular matrix (ECM)
deposition construct dual pathological barriers to drug delivery. Upon capillarization, the …
deposition construct dual pathological barriers to drug delivery. Upon capillarization, the …
[HTML][HTML] Nonalcoholic fatty liver disease and chronic kidney disease: epidemiology, pathogenesis, and clinical and research implications
Nonalcoholic fatty liver disease (NAFLD) has become the most common cause of chronic
liver disease worldwide, affecting up to~ 30% of adult populations. NAFLD defines a …
liver disease worldwide, affecting up to~ 30% of adult populations. NAFLD defines a …
Role of extracellular vesicles in liver diseases and their therapeutic potential
More than eight hundred million people worldwide have chronic liver disease, with two
million deaths per year. Recurring liver injury results in fibrogenesis, progressing towards …
million deaths per year. Recurring liver injury results in fibrogenesis, progressing towards …