Peptide nucleic acid (PNA) and its applications in chemical biology, diagnostics, and therapeutics

J Saarbach, PM Sabale, N Winssinger - Current opinion in chemical …, 2019 - Elsevier
Peptide nucleic acid (PNA) stands as one of the most successful artificial oligonucleotide
mimetics. Salient features include the stability of hybridization complexes (either as …

Therapeutic and diagnostic applications of antisense peptide nucleic acids

V MacLelland, M Kravitz, A Gupta - Molecular Therapy Nucleic Acids, 2024 - cell.com
Peptide nucleic acids (PNAs) are synthetic nucleic acid analogs with a neutral N-(2-
aminoethyl) glycine backbone. PNAs possess unique physicochemical characteristics such …

The current progress of tetrahedral DNA nanostructure for antibacterial application and bone tissue regeneration

S Hong, W Jiang, Q Ding, K Lin, C Zhao… - International journal of …, 2023 - Taylor & Francis
Recently, programmable assembly technologies have enabled the application of DNA in the
creation of new nanomaterials with unprecedented functionality. One of the most common …

[HTML][HTML] Chemical approaches to discover the full potential of peptide nucleic acids in biomedical applications

N Brodyagin, M Katkevics, V Kotikam… - Beilstein journal of …, 2021 - beilstein-journals.org
Peptide nucleic acid (PNA) is arguably one of the most successful DNA mimics, despite a
most dramatic departure from the native structure of DNA. The present review summarizes …

Structural dynamics influences the antibacterial activity of a cell-penetrating peptide (KFF)3K

J Macyszyn, P Chyży, M Burmistrz, M Lobka… - Scientific Reports, 2023 - nature.com
Given the widespread demand for novel antibacterial agents, we modified a cell-penetrating
peptide (KFF) 3K to transform it into an antibacterial peptide. Namely, we inserted a …

Advances in therapeutic bacterial antisense biotechnology

JP Hegarty, DB Stewart - Applied microbiology and biotechnology, 2018 - Springer
Antisense therapeutics are a biotechnological form of antibiotic therapy using chemical
analogues of short single-stranded nucleic acid sequences modified to form stable …

Antibacterial peptide nucleic acids—facts and perspectives

M Wojciechowska, M Równicki, A Mieczkowski… - Molecules, 2020 - mdpi.com
Antibiotic resistance is an escalating, worldwide problem. Due to excessive use of
antibiotics, multidrug-resistant bacteria have become a serious threat and a major global …

Emerging target-directed approaches for the treatment and diagnosis of microbial infections

MC Almeida, PM da Costa, E Sousa… - Journal of Medicinal …, 2022 - ACS Publications
With the rising levels of drug resistance, develo** efficient antimicrobial therapies has
become a priority. A promising strategy is the conjugation of antibiotics with relevant …

Advances in the delivery of antisense oligonucleotides for combating bacterial infectious diseases

XY Xue, XG Mao, Y Zhou, Z Chen, Y Hu, Z Hou… - … , Biology and Medicine, 2018 - Elsevier
Discovery and development of new antibacterial drugs against multidrug resistant bacterial
strains have become more and more urgent. Antisense oligonucleotides (ASOs) show …

Oligonucleotide probes for imaging and diagnosis of bacterial infections

L Moreira, NM Guimarães, RS Santos… - Critical Reviews in …, 2025 - Taylor & Francis
The rise of infectious diseases as a public health concern has necessitated the development
of rapid and precise diagnostic methods. Imaging techniques like nuclear and optical …