Peptide nucleic acid (PNA) and its applications in chemical biology, diagnostics, and therapeutics
Peptide nucleic acid (PNA) stands as one of the most successful artificial oligonucleotide
mimetics. Salient features include the stability of hybridization complexes (either as …
mimetics. Salient features include the stability of hybridization complexes (either as …
Therapeutic and diagnostic applications of antisense peptide nucleic acids
V MacLelland, M Kravitz, A Gupta - Molecular Therapy Nucleic Acids, 2024 - cell.com
Peptide nucleic acids (PNAs) are synthetic nucleic acid analogs with a neutral N-(2-
aminoethyl) glycine backbone. PNAs possess unique physicochemical characteristics such …
aminoethyl) glycine backbone. PNAs possess unique physicochemical characteristics such …
The current progress of tetrahedral DNA nanostructure for antibacterial application and bone tissue regeneration
S Hong, W Jiang, Q Ding, K Lin, C Zhao… - International journal of …, 2023 - Taylor & Francis
Recently, programmable assembly technologies have enabled the application of DNA in the
creation of new nanomaterials with unprecedented functionality. One of the most common …
creation of new nanomaterials with unprecedented functionality. One of the most common …
[HTML][HTML] Chemical approaches to discover the full potential of peptide nucleic acids in biomedical applications
Peptide nucleic acid (PNA) is arguably one of the most successful DNA mimics, despite a
most dramatic departure from the native structure of DNA. The present review summarizes …
most dramatic departure from the native structure of DNA. The present review summarizes …
Structural dynamics influences the antibacterial activity of a cell-penetrating peptide (KFF)3K
J Macyszyn, P Chyży, M Burmistrz, M Lobka… - Scientific Reports, 2023 - nature.com
Given the widespread demand for novel antibacterial agents, we modified a cell-penetrating
peptide (KFF) 3K to transform it into an antibacterial peptide. Namely, we inserted a …
peptide (KFF) 3K to transform it into an antibacterial peptide. Namely, we inserted a …
Advances in therapeutic bacterial antisense biotechnology
Antisense therapeutics are a biotechnological form of antibiotic therapy using chemical
analogues of short single-stranded nucleic acid sequences modified to form stable …
analogues of short single-stranded nucleic acid sequences modified to form stable …
Antibacterial peptide nucleic acids—facts and perspectives
Antibiotic resistance is an escalating, worldwide problem. Due to excessive use of
antibiotics, multidrug-resistant bacteria have become a serious threat and a major global …
antibiotics, multidrug-resistant bacteria have become a serious threat and a major global …
Emerging target-directed approaches for the treatment and diagnosis of microbial infections
MC Almeida, PM da Costa, E Sousa… - Journal of Medicinal …, 2022 - ACS Publications
With the rising levels of drug resistance, develo** efficient antimicrobial therapies has
become a priority. A promising strategy is the conjugation of antibiotics with relevant …
become a priority. A promising strategy is the conjugation of antibiotics with relevant …
Advances in the delivery of antisense oligonucleotides for combating bacterial infectious diseases
XY Xue, XG Mao, Y Zhou, Z Chen, Y Hu, Z Hou… - … , Biology and Medicine, 2018 - Elsevier
Discovery and development of new antibacterial drugs against multidrug resistant bacterial
strains have become more and more urgent. Antisense oligonucleotides (ASOs) show …
strains have become more and more urgent. Antisense oligonucleotides (ASOs) show …
Oligonucleotide probes for imaging and diagnosis of bacterial infections
L Moreira, NM Guimarães, RS Santos… - Critical Reviews in …, 2025 - Taylor & Francis
The rise of infectious diseases as a public health concern has necessitated the development
of rapid and precise diagnostic methods. Imaging techniques like nuclear and optical …
of rapid and precise diagnostic methods. Imaging techniques like nuclear and optical …