Aging is considered the deterioration of physiological functions along with an increased
mortality rate. This scientific review focuses on the central importance of genomic instability …

Satellite DNA consists of abundant tandem repeats that play important roles in cellular
processes, including chromosome segregation, genome organization and chromosome end …

Constitutive heterochromatin is a major component of the eukaryotic nucleus and is
essential for the maintenance of genome stability. Highly concentrated at pericentromeric …

Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …

Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion
of genetically variant hematopoietic cells that increases exponentially with age and is …

Glioblastoma (GBM) is a brain tumor that carries a dismal prognosis and displays
considerable heterogeneity. We have recently identified recurrent H3F3A mutations affecting …

Cancer arises as a consequence of cumulative disruptions to cellular growth control with
Darwinian selection for those heritable changes that provide the greatest clonal advantage …

Short telomeres cause age-related disease, and long telomeres contribute to cancer;
however, the mechanisms regulating telomere length are unclear. We developed a …

Loss of the de novo DNA methyltransferases Dnmt3a and Dnmt3b in embryonic stem cells
obstructs differentiation; however, the role of these enzymes in somatic stem cells is largely …

Background The genetic alterations responsible for an adverse outcome in most patients
with acute myeloid leukemia (AML) are unknown. Methods Using massively parallel DNA …