Abstract l-Tryptophan (Trp) metabolism through the kynurenine pathway (KP) is involved in
the regulation of immunity, neuronal function and intestinal homeostasis. Imbalances in Trp …

Recent evidence indicates that ionizing radiation can enhance immune responses to
tumors. Advances in radiation delivery techniques allow hypofractionated delivery of …

Small-molecule inhibitors of indoleamine 2, 3-dioxygenase-1 (IDO1) are emerging at the
vanguard of experimental agents in oncology. Here, pioneers of this new drug class provide …

Based on its effects on both tumour cell intrinsic malignant properties as well as anti-tumour
immune responses, tryptophan catabolism has emerged as an important metabolic regulator …

With immunotherapy enjoying a rapid resurgence based on the achievement of durable
remissions in some patients with agents that derepress immune function, commonly referred …

Abstract Indoleamine 2, 3-dioxygenase (IDO) as a principle enzyme in tryptophan (Trp)
catabolism, modulates immune responses and promotes cancer progression. In recent …

Indoleamine 2, 3-dioxygenase 1 (IDO1) is a cytosolic haem-containing enzyme involved in
the degradation of tryptophan to kynurenine. Although initially thought to be solely …

Emerging evidence indicates that the induction of radiotherapy (RT) on the immunogenic
cell death (ICD) is not only dependent on its direct cytotoxic effect, changes in the tumor …

Radiotherapy is a pivotal component in the curative treatment of patients with localised
cancer and isolated metastasis, as well as being used as a palliative strategy for patients …

Simple Summary Skin cancer is the most common cancer type worldwide, and melanoma is
its most aggressive and deadly form. In the past few decades, targeted therapy and …