Catechol-O-methyltransferase Val158Met polymorphism and clinical response to antipsychotic treatment in schizophrenia and schizo-affective disorder patients: a …
Background: The catechol-O-methyltransferase (COMT) enzyme plays a crucial role in
dopamine degradation, and the COMT Val158Met polymorphism (rs4680) is associated with …
dopamine degradation, and the COMT Val158Met polymorphism (rs4680) is associated with …
Inflammatory cytokines derived from peripheral blood contribute to the modified electroconvulsive therapy-induced cognitive deficits in major depressive disorder
H Tian, G Li, G Xu, J Liu, X Wan, J Zhang, S **e… - European archives of …, 2021 - Springer
Little is known about the pathophysiology of memory deficits in patients with major
depressive disorder (MDD) treated with modified electroconvulsive therapy (MECT). This …
depressive disorder (MDD) treated with modified electroconvulsive therapy (MECT). This …
Association study between COMT, DRD2, and DRD3 gene variants and antipsychotic treatment response in Mexican patients with schizophrenia
R Escamilla, B Camarena… - Neuropsychiatric …, 2018 - Taylor & Francis
Purpose The efficacy of schizophrenia treatments using antipsychotics (APs) has long been
established, but the benefit obtained by several patients using conventional APs (typical or …
established, but the benefit obtained by several patients using conventional APs (typical or …
Association studies of genomic variants with treatment response to risperidone, clozapine, quetiapine and chlorpromazine in the Chinese Han population
Schizophrenia is a widespread mental disease with a prevalence of about 1% in the world
population. Continuous long-term treatment is required to maintain social functioning and …
population. Continuous long-term treatment is required to maintain social functioning and …
Male-specific association between dopamine receptor D4 gene methylation and schizophrenia
J Cheng, Y Wang, K Zhou, L Wang, J Li, Q Zhuang… - PloS one, 2014 - journals.plos.org
Objective The goal of our study was to investigate whether DRD4 gene DNA methylation
played an important role in the susceptibility of Han Chinese SCZ. Methods Using the …
played an important role in the susceptibility of Han Chinese SCZ. Methods Using the …
Catechol-O-methyltransferase gene promoter methylation as a peripheral biomarker in male schizophrenia
S Gao, J Cheng, G Li, T Sun, Y Xu, Y Wang… - European …, 2017 - cambridge.org
As an epigenetic modification, DNA methylation may reflect the interaction between genetic
and environmental factors in the development of schizophrenia (SCZ). Catechol-O …
and environmental factors in the development of schizophrenia (SCZ). Catechol-O …
Metabolic syndrome in patients taking clozapine: prevalence and influence of catechol-O-methyltransferase genotype
Y Zhang, M Chen, J Chen, Z Wu, S Yu, Y Fang… - …, 2014 - Springer
Abstract Rationale Metabolic syndrome (MetS) has consistently been identified as an
adverse effect of long-term treatment with atypical antipsychotics (AAPs) such as clozapine …
adverse effect of long-term treatment with atypical antipsychotics (AAPs) such as clozapine …
[HTML][HTML] Association between the COMT Val158Met polymorphism and antipsychotic efficacy in schizophrenia: An updated meta-analysis
Background Catechol-O-methyltransferase (COMT) contributes to the control of synaptic
dopamine (DA) transmission by catalyzing DA degradation in the presynaptic space. The …
dopamine (DA) transmission by catalyzing DA degradation in the presynaptic space. The …
Impact of NTRK2, DRD2 and ACE polymorphisms on prolactin levels in antipsychotic-treated patients with first-episode psychosis
Background: Hyperprolactinemia is a common side-effect of antipsychotics (APs), which may
trigger serious secondary problems and compromise the adherence to treatment which is …
trigger serious secondary problems and compromise the adherence to treatment which is …
The role of BDNF exon I region methylation in the treatment of depression with sertraline and its clinical diagnostic value
Y **ng, T Sun, G Li, G Xu, J Cheng… - Journal of Clinical …, 2021 - Wiley Online Library
Background Brain‐derived neurotrophic factor (BDNF) is considered to be one of the best
candidate genes for depression. However, whether sertraline treatment affects the …
candidate genes for depression. However, whether sertraline treatment affects the …