Major depressive disorder

W Marx, BWJH Penninx, M Solmi… - Nature Reviews …, 2023 - nature.com
Major depressive disorder (MDD) is characterized by persistent depressed mood, loss of
interest or pleasure in previously enjoyable activities, recurrent thoughts of death, and …

Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications

AN Tartt, MB Mariani, R Hen, JJ Mann… - Molecular psychiatry, 2022 - nature.com
Major depressive disorder (MDD) was previously hypothesized to be a disease of
monoamine deficiency in which low levels of monoamines in the synaptic cleft were …

The 2020 Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders

GS Malhi, E Bell, D Bassett, P Boyce… - Australian & New …, 2021 - journals.sagepub.com
Objectives: To provide advice and guidance regarding the management of mood disorders,
derived from scientific evidence and supplemented by expert clinical consensus to formulate …

The C Factor: Cognitive dysfunction as a transdiagnostic dimension in psychopathology

A Abramovitch, T Short, A Schweiger - Clinical Psychology Review, 2021 - Elsevier
Research into cognitive functions across psychological disorders suggests that cognitive
deficiencies may be present across multiple disorders, potentially pointing to a …

The global prevalence of depression, anxiety, stress, and insomnia among general population during COVID-19 pandemic: A systematic review and meta-analysis

S Mahmud, M Mohsin, MN Dewan, A Muyeed - Trends in Psychology, 2023 - Springer
This study aimed to examine research findings related to depression, anxiety, stress, and
insomnia during the COVID-19 pandemic. This study also explored periodic changes in the …

Is depression a global brain disorder with topographic dynamic reorganization?

G Northoff, D Hirjak - Translational Psychiatry, 2024 - nature.com
Major depressive disorder (MDD) is characterized by a multitude of psychopathological
symptoms including affective, cognitive, perceptual, sensorimotor, and social. The neuronal …

Prevalence, risk factors and clinical correlates of depression in quarantined population during the COVID-19 outbreak

M Peng, B Mo, Y Liu, M Xu, X Song, L Liu… - Journal of affective …, 2020 - Elsevier
Background The COVID-19 outbreak has brought tremendous psychological pressure to the
general population, which may lead to depression. Therefore, this study aim to evaluate the …

An investigation of working memory deficits in depression using the n-back task: A systematic review and meta-analysis

S Nikolin, YY Tan, A Schwaab, A Moffa, CK Loo… - Journal of Affective …, 2021 - Elsevier
Background Depression is associated with cognitive deficits across multiple domains,
including working memory. The n-back task, a convenient psychometric tool capable of …

Altered GABA-mediated information processing and cognitive dysfunctions in depression and other brain disorders

T Prévot, E Sibille - Molecular psychiatry, 2021 - nature.com
Cognitive dysfunctions, including impaired attention, learning, memory, planning and
problem solving, occur in depressive episodes, often persist during remission, predict …

Cognitive impairment and neurocognitive profiles in major depression—a clinical perspective

Å Hammar, EH Ronold, GÅ Rekkedal - Frontiers in Psychiatry, 2022 - frontiersin.org
Increasingly, studies have investigated cognitive functioning from the perspective of acute
state-to remitted phases of Major Depressive Disorder (MDD). Some cognitive deficits …