Abstract Stress Granules (SGs) are membraneless cytoplasmic RNA granules, which
contain translationally stalled mRNAs, associated translation initiation factors and multiple …

Intercellular communication between neurons and their surrounding cells occurs through the
secretion of soluble molecules or release of vesicles such as exosomes into the extracellular …

A GGGGCC24+ hexanucleotide repeat expansion (HRE) in the C9ORF72 gene is the most
common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia …

Heterogenous nuclear ribonucleoproteins (hnRNPs) are a complex and functionally diverse
family of RNA binding proteins with multifarious roles. They are involved, directly or …

Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is an incurable
neurodegenerative condition, characterized by the loss of upper and lower motor neurons. It …

In the ongoing process of uncovering molecular abnormalities in neurodegenerative
diseases characterized by toxic protein aggregates, nucleo-cytoplasmic transport defects …

Background The characterisation of presymptomatic disease-burden patterns in
asymptomatic mutation carriers has a dual academic and clinical relevance. The …

Glial cells are key players in the proper formation and maintenance of the nervous system,
thus contributing to neuronal health and disease in humans. However, little is known about …

Over the past 20 years, analyses of single brain cell genomes have revealed that the brain is
composed of cells with myriad distinct genomes: the brain is a genomic mosaic, generated …

The complexity of neurodegeneration restricts the ability to understand and treat the
neurological disorders affecting millions of people worldwide. Therefore, there is an unmet …