Optogenetics is widely used to interrogate the neural circuits underlying disease and has
most recently been harnessed for therapeutic applications. The optogenetic toolkit consists …

Directed evolution has proved to be an effective strategy for improving or altering the activity
of biomolecules for industrial, research and therapeutic applications. The evolution of …

A technology that simultaneously records membrane potential from multiple neurons in
behaving animals will have a transformative effect on neuroscience research,. Genetically …

Motivation Machine-learning models trained on protein sequences and their measured
functions can infer biological properties of unseen sequences without requiring an …

We developed a new way to engineer complex proteins toward multidimensional
specifications using a simple, yet scalable, directed evolution strategy. By robotically picking …

The ability to optically image cellular transmembrane voltages at millisecond-timescale
resolutions can offer unprecedented insight into the function of living brains in behaving …

Highlights•Recent advances in genetically encoded voltage indicators (GEVIs) have brought
neural voltage imaging in vivo within reach.•Recently introduced tools such as electrically …

The understanding of how the rhodopsin sequence can be modified to exactly modulate the
spectroscopic properties of its retinal chromophore, is a prerequisite for the rational design …

The historically understood role of the central amygdala (CeA) in fear learning is to serve as
a passive output station for processing and plasticity that occurs elsewhere in the brain …

The Rhizoclosmatium globosum genome encodes three rhodopsin-guanylyl cyclases
(RGCs), which are predicted to facilitate visual orientation of the fungal zoospores. Here, we …