Proteomics, the study of all the proteins in biological systems, is becoming a data‐rich
science. Protein sequences and structures are comprehensively catalogued in online …

TMEM16 proteins, also known as anoctamins, are involved in a variety of functions that
include ion transport, phospholipid scrambling, and regulation of other membrane proteins …

Tobacco smoking is positively correlated with non-alcoholic fatty liver disease (NAFLD),,,–,
but the underlying mechanism for this association is unclear. Here we report that nicotine …

Protein phosphorylation, catalyzed by protein kinases (PKs), is one of the most important
post-translational modifications (PTMs), and involved in regulating almost all of biological …

In eukaryotes, protein phosphorylation is specifically catalyzed by numerous protein kinases
(PKs), faithfully orchestrates various biological processes, and reversibly determines cellular …

Chaperone-mediated autophagy (CMA) is a lysosome-dependent selective degradation
pathway implicated in the pathogenesis of cancer and neurodegenerative diseases …

Autophagy is a cellular catabolic process that relies on the cooperation of autophagosomes
and lysosomes. During starvation, the cell expands both compartments to enhance …

Accumulating evidence has shown that dysfunctional mitochondria can be selectively
removed by mitophagy. Dysregulation of mitophagy is implicated in the development of …

Aberrant signaling through the class I phosphatidylinositol 3-kinase (PI3K)–Akt axis is
frequent in human cancer. Here, we show that Beclin 1, an essential autophagy and tumor …

The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) regulates cell death. We
sought to determine whether DNA-PKcs played a role in the tubular damage that occurs …