Extracellular vesicles (EVs) are nano-sized lipid bilayer vesicles released by virtually every
cell type. EVs have diverse biological activities, ranging from roles in development and …

Extracellular vesicles (EVs) are nanosized lipid bilayer vesicles that are released by almost
all cell types. They range in diameter from 30 nm to several micrometres and have the ability …

Autophagy is markedly impaired in Alzheimer's disease (AD). Here we reveal unique
autophagy dysregulation within neurons in five AD mouse models in vivo and identify its …

Microglia, the resident immune cells of the brain, have emerged as crucial regulators of
synaptic refinement and brain wiring. However, whether the remodeling of distinct synapse …

Effective protein quality control (PQC), essential for cellular health, relies on spatial
sequestration of misfolded proteins into defined inclusions. Here we reveal the coordination …

For a long time, optical imaging of the deep brain with high resolution has been a challenge.
Recently, with the advance in second near‐infrared (NIR‐II) bioimaging techniques and …

Industrial fermentation processes strive for high robustness to ensure optimal and consistent
performance. Medium components, fermentation products, and physical perturbations may …

Membrane structural integrity is essential for optimal mitochondrial function. These
organelles produce the energy needed for all vital processes, provided their outer and inner …

Partial phagocytosis—called trogocytosis—of axons by microglia has been documented in
ex vivo preparations but has not been directly observed in vivo. The mechanisms that …

The guts of neonatal mammals and stomachless fish have a limited capacity for luminal
protein digestion, which allows oral acquisition of antibodies and antigens. However, how …