Antibiotics—compounds that are literally 'against life'—are typically antibacterial drugs,
interfering with some structure or process that is essential to bacterial growth or survival …

Polyketide biosynthesis: a millennium review - Natural Product Reports (RSC Publishing)
DOI:10.1039/A909079G Royal Society of Chemistry View PDF VersionPrevious ArticleNext Article …

The replacement of multistep, salt-generating chemical synthesis with efficient catalyzed
reactions that strive for atom economy1 is having a significant impact on the manufacture of …

Biological signaling pathways interact with one another to form complex networks.
Complexity arises from the large number of components, many with isoforms that have …

Polyketides and non-ribosomal peptides are two large families of complex natural products
that are built from simple carboxylic acid or amino acid monomers, respectively, and that …

During the last 100 years, cell signaling has evolved into a common mechanism for most
physiological processes across systems. Although the majority of cell signaling principles …

As long as the molecular complexity increases, the number of chemical transformations will
increase in parallel, becoming a highly demanding synthetic process in terms of time and …

Covering: up to early 2001The biosynthesis and mode of attachment of a wide range of
polyketide synthase (PKS) starter units in bacteria are covered in this review. Natural …

Covering: mid 1990s to 2018 Over the last two decades, diverse approaches have been
explored to generate new polyketides by engineering polyketide synthases (PKSs) …

Covering: up to 2015 Multienzyme polyketide synthases (PKSs) are molecular-scale
assembly lines which construct complex natural products in bacteria. The underlying …