The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

Almost 40 years since the discovery of microtubule dynamic instability, the molecular
mechanisms underlying microtubule dynamics remain an area of intense research interest …

During mitosis, microtubules in the spindle turn over continuously. At spindle poles, where
microtubule minus ends are concentrated, microtubule nucleation and depolymerization, the …

Cytoplasmic linker-associated proteins (CLASPs) regulate microtubules in fundamental
cellular processes. CLASPs stabilize dynamic microtubules by suppressing microtubule …

The GTP-tubulin cap is widely accepted to protect microtubules against catastrophe. The
GTP-cap size is thought to increase with the microtubule growth rate, presumably endowing …

Microtubules are dynamic cytoskeletal filaments that undergo stochastic switching between
phases of polymerization and depolymerization—a behavior known as dynamic instability …

Elongator is a tRNA-modifying complex that regulates protein translation. Recently, a
moonlighting function of Elongator has been identified in regulating the polarization of the …

Microtubule-based cytoskeletal structures aid in cell motility, cell polarization, and
intracellular transport. These functions require a coordinated effort of regulatory proteins …

The microtubule array, assembled into the mitotic spindle, polymerises from the
centrosomes and the chromosomes in many organisms. Their plus ends alternate between …

Microtubules (MTs) often form a polarized array with minus ends anchored at the
centrosome and plus ends extended toward the cell margins. Plus ends display behavior …