Applications of multi‐omics analysis in human diseases

C Chen, J Wang, D Pan, X Wang, Y Xu, J Yan… - MedComm, 2023 - Wiley Online Library
Multi‐omics usually refers to the crossover application of multiple high‐throughput screening
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …

Machine learning meets omics: applications and perspectives

R Li, L Li, Y Xu, J Yang - Briefings in Bioinformatics, 2022 - academic.oup.com
The innovation of biotechnologies has allowed the accumulation of omics data at an
alarming rate, thus introducing the era of 'big data'. Extracting inherent valuable knowledge …

[HTML][HTML] A quantitative proteome map of the human body

L Jiang, M Wang, S Lin, R Jian, X Li, J Chan, G Dong… - Cell, 2020 - cell.com
Determining protein levels in each tissue and how they compare with RNA levels is
important for understanding human biology and disease as well as regulatory processes …

Undisclosed, unmet and neglected challenges in multi-omics studies

S Tarazona, A Arzalluz-Luque, A Conesa - Nature Computational …, 2021 - nature.com
Multi-omics approaches have become a reality in both large genomics projects and small
laboratories. However, the multi-omics research community still faces a number of issues …

Abnormal brain cholesterol homeostasis in Alzheimer's disease—a targeted metabolomic and transcriptomic study

VR Varma, H Büşra Lüleci, AM Oommen… - npj Aging and …, 2021 - nature.com
The role of brain cholesterol metabolism in Alzheimer's disease (AD) remains unclear.
Peripheral and brain cholesterol levels are largely independent due to the impermeability of …

[HTML][HTML] Integrating omics data in genome-scale metabolic modeling: a methodological perspective for precision medicine

P Sen, M Orešič - Metabolites, 2023 - mdpi.com
Recent advancements in omics technologies have generated a wealth of biological data.
Integrating these data within mathematical models is essential to fully leverage their …

[HTML][HTML] Metabolomics and multi-omics integration: a survey of computational methods and resources

T Eicher, G Kinnebrew, A Patt, K Spencer, K Ying, Q Ma… - Metabolites, 2020 - mdpi.com
As researchers are increasingly able to collect data on a large scale from multiple clinical
and omics modalities, multi-omics integration is becoming a critical component of …

Ten quick tips for avoiding pitfalls in multi-omics data integration analyses

D Chicco, F Cumbo, C Angione - PLoS computational biology, 2023 - journals.plos.org
Data are the most important elements of bioinformatics: Computational analysis of
bioinformatics data, in fact, can help researchers infer new knowledge about biology …

Overtraining syndrome as a complex systems phenomenon

LE Armstrong, MF Bergeron, EC Lee… - Frontiers in network …, 2022 - frontiersin.org
The phenomenon of reduced athletic performance following sustained, intense training
(Overtraining Syndrome, and OTS) was first recognized more than 90 years ago. Although …

Deep learning meets metabolomics: a methodological perspective

P Sen, S Lamichhane, VB Mathema… - Briefings in …, 2021 - academic.oup.com
Deep learning (DL), an emerging area of investigation in the fields of machine learning and
artificial intelligence, has markedly advanced over the past years. DL techniques are being …