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Applications of multi‐omics analysis in human diseases
Multi‐omics usually refers to the crossover application of multiple high‐throughput screening
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …
Machine learning meets omics: applications and perspectives
The innovation of biotechnologies has allowed the accumulation of omics data at an
alarming rate, thus introducing the era of 'big data'. Extracting inherent valuable knowledge …
alarming rate, thus introducing the era of 'big data'. Extracting inherent valuable knowledge …
[HTML][HTML] A quantitative proteome map of the human body
Determining protein levels in each tissue and how they compare with RNA levels is
important for understanding human biology and disease as well as regulatory processes …
important for understanding human biology and disease as well as regulatory processes …
Undisclosed, unmet and neglected challenges in multi-omics studies
Multi-omics approaches have become a reality in both large genomics projects and small
laboratories. However, the multi-omics research community still faces a number of issues …
laboratories. However, the multi-omics research community still faces a number of issues …
Abnormal brain cholesterol homeostasis in Alzheimer's disease—a targeted metabolomic and transcriptomic study
VR Varma, H Büşra Lüleci, AM Oommen… - npj Aging and …, 2021 - nature.com
The role of brain cholesterol metabolism in Alzheimer's disease (AD) remains unclear.
Peripheral and brain cholesterol levels are largely independent due to the impermeability of …
Peripheral and brain cholesterol levels are largely independent due to the impermeability of …
[HTML][HTML] Integrating omics data in genome-scale metabolic modeling: a methodological perspective for precision medicine
Recent advancements in omics technologies have generated a wealth of biological data.
Integrating these data within mathematical models is essential to fully leverage their …
Integrating these data within mathematical models is essential to fully leverage their …
[HTML][HTML] Metabolomics and multi-omics integration: a survey of computational methods and resources
As researchers are increasingly able to collect data on a large scale from multiple clinical
and omics modalities, multi-omics integration is becoming a critical component of …
and omics modalities, multi-omics integration is becoming a critical component of …
Ten quick tips for avoiding pitfalls in multi-omics data integration analyses
Data are the most important elements of bioinformatics: Computational analysis of
bioinformatics data, in fact, can help researchers infer new knowledge about biology …
bioinformatics data, in fact, can help researchers infer new knowledge about biology …
Overtraining syndrome as a complex systems phenomenon
The phenomenon of reduced athletic performance following sustained, intense training
(Overtraining Syndrome, and OTS) was first recognized more than 90 years ago. Although …
(Overtraining Syndrome, and OTS) was first recognized more than 90 years ago. Although …
Deep learning meets metabolomics: a methodological perspective
Deep learning (DL), an emerging area of investigation in the fields of machine learning and
artificial intelligence, has markedly advanced over the past years. DL techniques are being …
artificial intelligence, has markedly advanced over the past years. DL techniques are being …