Biomarkers for Alzheimer's disease—preparing for a new era of disease-modifying therapies
Clinical trial results presented in 2019 suggest that antibody-based removal of cerebral
amyloid β (Aβ) plaques may possibly clear tau tangles and modestly slow cognitive decline …
amyloid β (Aβ) plaques may possibly clear tau tangles and modestly slow cognitive decline …
The use of neuroimaging techniques in the early and differential diagnosis of dementia
Dementia is a leading cause of disability and death worldwide. At present there is no
disease modifying treatment for any of the most common types of dementia such as …
disease modifying treatment for any of the most common types of dementia such as …
[HTML][HTML] Challenges for biophysical modeling of microstructure
The biophysical modeling efforts in diffusion MRI have grown considerably over the past 25
years. In this review, we dwell on the various challenges along the journey of bringing a …
years. In this review, we dwell on the various challenges along the journey of bringing a …
Measures of cortical microstructure are linked to amyloid pathology in Alzheimer's disease
Markers of downstream events are a key component of clinical trials of disease-modifying
therapies for Alzheimer's disease. Morphological metrics like cortical thickness are …
therapies for Alzheimer's disease. Morphological metrics like cortical thickness are …
Diffusion magnetic resonance imaging-based biomarkers for neurodegenerative diseases
There has been an increasing prevalence of neurodegenerative diseases with the rapid
increase in aging societies worldwide. Biomarkers that can be used to detect pathological …
increase in aging societies worldwide. Biomarkers that can be used to detect pathological …
Diffusion models reveal white matter microstructural changes with ageing, pathology and cognition
White matter microstructure undergoes progressive changes during the lifespan, but the
neurobiological underpinnings related to ageing and disease remains unclear. We used an …
neurobiological underpinnings related to ageing and disease remains unclear. We used an …
Neuroimaging of tissue microstructure as a marker of neurodegeneration in the AT (N) framework: defining abnormal neurodegeneration and improving prediction of …
Background Alzheimer's disease involves accumulating amyloid (A) and tau (T) pathology,
and progressive neurodegeneration (N), leading to the development of the AD clinical …
and progressive neurodegeneration (N), leading to the development of the AD clinical …
White matter damage due to vascular, tau, and TDP-43 pathologies and its relevance to cognition
Multi-compartment modelling of white matter microstructure using Neurite Orientation
Dispersion and Density Imaging (NODDI) can provide information on white matter health …
Dispersion and Density Imaging (NODDI) can provide information on white matter health …
Associations between diffusion MRI microstructure and cerebrospinal fluid markers of Alzheimer's disease pathology and neurodegeneration along the Alzheimer's …
JF Moody, DC Dean III, SR Kecskemeti… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction White matter (WM) degeneration is a critical component of early Alzheimer's
disease (AD) pathophysiology. Diffusion‐weighted imaging (DWI) models, including …
disease (AD) pathophysiology. Diffusion‐weighted imaging (DWI) models, including …