A molecular view of kinetochore assembly and function
Kinetochores are large protein assemblies that connect chromosomes to microtubules of the
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …
The four causes: the functional architecture of centromeres and kinetochores
Kinetochores are molecular machines that power chromosome segregation during the
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …
circTP63 functions as a ceRNA to promote lung squamous cell carcinoma progression by upregulating FOXM1
Circular RNAs (circRNAs) are identified as vital regulators in a variety of cancers. However,
the role of circRNA in lung squamous cell carcinoma (LUSC) remains largely unknown …
the role of circRNA in lung squamous cell carcinoma (LUSC) remains largely unknown …
Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome
Kinetochores assemble onto specialized centromeric CENP-A (centromere protein A)
nucleosomes (CENP-ANuc) to mediate attachments between chromosomes and the mitotic …
nucleosomes (CENP-ANuc) to mediate attachments between chromosomes and the mitotic …
Structure of the human inner kinetochore CCAN complex and its significance for human centromere organization
Centromeres are specialized chromosome loci that seed the kinetochore, a large protein
complex that effects chromosome segregation. A 16-subunit complex, the constitutive …
complex that effects chromosome segregation. A 16-subunit complex, the constitutive …
BUB1 and CENP-U, primed by CDK1, are the main PLK1 kinetochore receptors in mitosis
Reflecting its pleiotropic functions, Polo-like kinase 1 (PLK1) localizes to various sub-cellular
structures during mitosis. At kinetochores, PLK1 contributes to microtubule attachments and …
structures during mitosis. At kinetochores, PLK1 contributes to microtubule attachments and …
Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome
In eukaryotes, accurate chromosome segregation in mitosis and meiosis maintains genome
stability and prevents aneuploidy. Kinetochores are large protein complexes that, by …
stability and prevents aneuploidy. Kinetochores are large protein complexes that, by …
The cell cycle, cancer development and therapy
E Jamasbi, M Hamelian, MA Hossain… - Molecular biology reports, 2022 - Springer
The process of cell division plays a vital role in cancer progression. Cell proliferation and
error-free chromosomes segregation during mitosis are central events in life cycle. Mistakes …
error-free chromosomes segregation during mitosis are central events in life cycle. Mistakes …
Structure of the MIS12 complex and molecular basis of its interaction with CENP-C at human kinetochores
A Petrovic, J Keller, Y Liu, K Overlack, J John… - Cell, 2016 - cell.com
Kinetochores, multisubunit protein assemblies, connect chromosomes to spindle
microtubules to promote chromosome segregation. The 10-subunit KMN assembly …
microtubules to promote chromosome segregation. The 10-subunit KMN assembly …
Kinase and phosphatase cross-talk at the kinetochore
AT Saurin - Frontiers in cell and developmental biology, 2018 - frontiersin.org
Multiple kinases and phosphatases act on the kinetochore to control chromosome
segregation: Aurora B, Mps1, Bub1, Plk1, Cdk1, PP1, and PP2A-B56, have all been shown …
segregation: Aurora B, Mps1, Bub1, Plk1, Cdk1, PP1, and PP2A-B56, have all been shown …