Cells are the fundamental units of life, and like all life forms, they change over time. Changes
in cell state are driven by molecular processes; of these many are initiated when molecule …

BACKGROUND: Ca2+ is a ubiquitous and versatile second messenger that transmits
information through changes of the cytosolic Ca2+ concentration. Recent investigations …

The interactions between mathematics and physiology have a long and illustrious history, of
which the study of calcium signalling is but a small chapter. Nevertheless, for those involved …

Abstract Changes in cellular Ca 2+ concentration control a wide range of physiological
processes, from the subsecond release of synaptic neurotransmitters, to the regulation of …

Abstract Intracellular calcium (Ca 2+) plays a significant role in many cell signaling
pathways, some of which are localized to spatially restricted microdomains. Ca 2+ binding …

Localized intracellular Ca2+ elevations known as puffs and sparks arise from the
cooperative activity of inositol 1, 4, 5-trisphosphate receptor Ca2+ channels (IP3Rs) and …

We investigate the key characteristics of Ca 2+ puffs in deterministic and stochastic
frameworks that all incorporate the cellular morphology of IP 3 receptor channel clusters. In …

In many cell types, the inositol trisphosphate receptor (IPR) is one of the important
components that control intracellular calcium dynamics, and an understanding of this …

Cardiac alternans is a beat-to-beat alternation in action potential duration (APD) and
intracellular calcium (Ca 2+) cycling seen in cardiac myocytes under rapid pacing that is …

Important biological processes like cell signalling and gene expression have noisy
components and are very complex at the same time. Mathematical analysis of such systems …