Proteomics is an increasingly powerful and indispensable technology in molecular cell
biology. It can be used to identify the components of small protein complexes and large …

Proteomics is the systematic study of the many and diverse properties of proteins in a
parallel manner with the aim of providing detailed descriptions of the structure, function and …

Cells from all kingdoms of life produce extracellular vesicles (EVs). Their cargo is protected
from the environment by the surrounding lipid bilayer. EVs from many organisms have been …

A statistical model is presented for computing probabilities that proteins are present in a
sample on the basis of peptides assigned to tandem mass (MS/MS) spectra acquired from a …

We present a statistical model to estimate the accuracy of peptide assignments to tandem
mass (MS/MS) spectra made by database search applications such as SEQUEST …

Almost all large-scale projects in mass spectrometry-based proteomics use trypsin to convert
protein mixtures into more readily analyzable peptide populations. When searching peptide …

The fungal pathogen Candida albicans can form biofilms that protect it from drugs and the
immune system. The biofilm cells release extracellular vesicles (EVs) that promote …

We present a novel scoring method for de novo interpretation of peptides from tandem mass
spectrometry data. Our scoring method uses a probabilistic network whose structure reflects …

Blood serum is a complex body fluid that contains various proteins ranging in concentration
over at least 9 orders of magnitude. Using a combination of mass spectrometry technologies …

A novel database search algorithm is presented for the qualitative identification of proteins
over a wide dynamic range, both in simple and complex biological samples. The algorithm …