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[HTML][HTML] Strategies for analyzing bisulfite sequencing data
K Wreczycka, A Gosdschan, D Yusuf, B Grüning… - Journal of …, 2017 - Elsevier
DNA methylation is one of the main epigenetic modifications in the eukaryotic genome; it
has been shown to play a role in cell-type specific regulation of gene expression, and …
has been shown to play a role in cell-type specific regulation of gene expression, and …
Statistical methods for detecting differentially methylated loci and regions
MD Robinson, A Kahraman, CW Law, H Lindsay… - Frontiers in …, 2014 - frontiersin.org
DNA methylation, the reversible addition of methyl groups at CpG dinucleotides, represents
an important regulatory layer associated with gene expression. Changed methylation status …
an important regulatory layer associated with gene expression. Changed methylation status …
Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species
D Anastasiadi, A Esteve-Codina, F Piferrer - Epigenetics & chromatin, 2018 - Springer
Background DNA methylation is one of the main epigenetic mechanisms for the regulation of
gene expression in eukaryotes. In the standard model, methylation in gene promoters has …
gene expression in eukaryotes. In the standard model, methylation in gene promoters has …
A Bayesian hierarchical model to detect differentially methylated loci from single nucleotide resolution sequencing data
H Feng, KN Conneely, H Wu - Nucleic acids research, 2014 - academic.oup.com
DNA methylation is an important epigenetic modification that has essential roles in cellular
processes including gene regulation, development and disease and is widely dysregulated …
processes including gene regulation, development and disease and is widely dysregulated …
De novo identification of differentially methylated regions in the human genome
TJ Peters, MJ Buckley, AL Statham, R Pidsley… - Epigenetics & …, 2015 - Springer
Background The identification and characterisation of differentially methylated regions
(DMRs) between phenotypes in the human genome is of prime interest in epigenetics. We …
(DMRs) between phenotypes in the human genome is of prime interest in epigenetics. We …
DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling
OA Guryanova, K Shank, B Spitzer, L Luciani… - Nature medicine, 2016 - nature.com
Although the majority of patients with acute myeloid leukemia (AML) initially respond to
chemotherapy, many of them subsequently relapse, and the mechanistic basis for AML …
chemotherapy, many of them subsequently relapse, and the mechanistic basis for AML …
Aging human hematopoietic stem cells manifest profound epigenetic reprogramming of enhancers that may predispose to leukemia
ER Adelman, HT Huang, A Roisman, A Olsson… - Cancer …, 2019 - aacrjournals.org
Aging is associated with functional decline of hematopoietic stem cells (HSC) as well as an
increased risk of myeloid malignancies. We performed an integrative characterization of …
increased risk of myeloid malignancies. We performed an integrative characterization of …
[HTML][HTML] Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia
AH Shih, Y Jiang, C Meydan, K Shank, S Pandey… - Cancer cell, 2015 - cell.com
Specific combinations of acute myeloid leukemia (AML) disease alleles, including FLT3 and
TET2 mutations, confer distinct biologic features and adverse outcome. We generated mice …
TET2 mutations, confer distinct biologic features and adverse outcome. We generated mice …
The loss of TET2 promotes CD8+ T cell memory differentiation
SA Carty, M Gohil, LB Banks, RM Cotton… - The Journal of …, 2018 - journals.aai.org
T cell differentiation requires appropriate regulation of DNA methylation. In this article, we
demonstrate that the methylcytosine dioxygenase ten-eleven translocation (TET) 2 regulates …
demonstrate that the methylcytosine dioxygenase ten-eleven translocation (TET) 2 regulates …
Migration‐related phenotypic divergence is associated with epigenetic modifications in rainbow trout
MR Baerwald, MH Meek, MR Stephens… - Molecular …, 2016 - Wiley Online Library
Migration is essential for the reproduction and survival of many animals, yet little is
understood about its underlying molecular mechanisms. We used the salmonid …
understood about its underlying molecular mechanisms. We used the salmonid …