Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …

In recent years, more and more single-cell technologies have been developed. A vast
amount of single-cell omics data has been generated by large projects, such as the Human …

Beyond their many well-established biological aberrations, solid tumours create an
abnormal physical microenvironment that fuels cancer progression and confers treatment …

Although biochemical regulation has been extensively studied in organoid modeling
protocols, the role of mechanoregulation in directing stem cell fate and organoid …

Physical forces are prominent during tumor progression. However, it is still unclear how they
impact and drive the diverse phenotypes found in cancer. Here, we apply an integrative …

Epithelial–mesenchymal transition (EMT) and its reverse mesenchymal–epithelial transition
(MET) are critical during embryonic development, wound healing and cancer metastasis …

Life, as a dense manifestation of soft matter, undergoes changes in water content,
biomacromolecular concentrations, condensation and crowding due to volumetric …

Fluctuations in the number of regulatory molecules and differences in timings of molecular
events can generate variation in gene expression among genetically identical cells in the …

Introduction: Metastasis is a major cause of cancer-related deaths, underscoring the
necessity to discern the rules and patterns of cancer cell spreading. Epithelial-mesenchymal …

The expression level of a gene can vary between genetically identical cells under the same
environmental condition—a phenomenon referred to as gene expression noise. Several …