Recent evidence clearly shows that cells respond to various physical cues in their
environments, guiding many cellular processes and tissue morphogenesis, pathology, and …

The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

Cells have evolved multiple mechanisms to apprehend and adapt finely to their
environment. Here we report a new cellular ability, which we term “curvotaxis” that enables …

Topography of the extracellular environment is now recognized as a major biophysical
regulator of cell behavior and function. The study of the influence of patterned substrates on …

Reproduction of the anatomical structures and functions of tissues using cells and designed
3D scaffolds is an ongoing challenge. For this, scaffolds with appropriate biomorphic …

In biological systems, form and function are inherently correlated. Despite this strong
interdependence, the biological effect of curvature has been largely overlooked or …

The dynamics of cell mechanics and epigenetic signatures direct cell behaviour and fate,
thus influencing regenerative outcomes. In recent years, the utilisation of 2D geometric (ie …

Adherent cells residing within tissues or biomaterials are presented with 3D geometrical
cues from their environment, often in the form of local surface curvatures. While there is …

Contact guidance for cell outgrowth refers to the phenomenon of the topography of the
extracellular matrix regulating cell behaviors and functions. In tissue engineering, scaffolds …

The function of most immune cells depends on their ability to migrate through complex
microenvironments, either randomly to patrol for the presence of antigens or directionally to …