Tricks with tetramers: how to get the most from multimeric peptide–MHC
The development of fluorochrome‐conjugated peptide–major histocompatibility complex
(pMHC) multimers in conjunction with continuing advances in flow cytometry has …
(pMHC) multimers in conjunction with continuing advances in flow cytometry has …
Structure, function, and immunomodulation of the CD8 co-receptor
Expressed on the surface of CD8+ T cells, the CD8 co-receptor is a key component of the T
cells that contributes to antigen recognition, immune cell maturation, and immune cell …
cells that contributes to antigen recognition, immune cell maturation, and immune cell …
PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection
Here, we report on the expression of programmed death (PD)-1 on human virus-specific
CD8+ T cells and the effect of manipulating signaling through PD-1 on the survival …
CD8+ T cells and the effect of manipulating signaling through PD-1 on the survival …
Lymph node sharing between pancreas, gut, and liver leads to immune crosstalk and regulation of pancreatic autoimmunity
H Brown, MR Komnick, PH Brigleb, TS Dermody… - Immunity, 2023 - cell.com
Lymph nodes (LNs) are critical sites for sha** tissue-specific adaptive immunity. However,
the impact of LN sharing between multiple organs on such tailoring is less understood. Here …
the impact of LN sharing between multiple organs on such tailoring is less understood. Here …
Directed evolution of human T-cell receptors with picomolar affinities by phage display
Y Li, R Moysey, PE Molloy, AL Vuidepot, T Mahon… - Nature …, 2005 - nature.com
Peptides derived from almost all proteins, including disease-associated proteins, can be
presented on the cell surface as peptide–human leukocyte antigen (pHLA) complexes. T …
presented on the cell surface as peptide–human leukocyte antigen (pHLA) complexes. T …
CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery
The activation of T lymphocytes (T cells) requires signaling through the T-cell receptor
(TCR). The role of the coreceptor molecules, CD4 and CD8, is not clear, although they are …
(TCR). The role of the coreceptor molecules, CD4 and CD8, is not clear, although they are …
Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses
The forces that govern clonal selection during the genesis and maintenance of specific T cell
responses are complex, but amenable to decryption by interrogation of constituent …
responses are complex, but amenable to decryption by interrogation of constituent …
Gene transfer of tumor-reactive TCR confers both high avidity and tumor reactivity to nonreactive peripheral blood mononuclear cells and tumor-infiltrating …
LA Johnson, B Heemskerk, DJ Powell… - The Journal of …, 2006 - journals.aai.org
Cell-based antitumor immunity is driven by CD8+ cytotoxic T cells bearing TCR that
recognize specific tumor-associated peptides bound to class I MHC molecules. Of several …
recognize specific tumor-associated peptides bound to class I MHC molecules. Of several …
Quantum dot semiconductor nanocrystals for immunophenoty** by polychromatic flow cytometry
Immune responses arise from a wide variety of cells expressing unique combinations of
multiple cell-surface proteins. Detailed characterization is hampered, however, by limitations …
multiple cell-surface proteins. Detailed characterization is hampered, however, by limitations …
Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization
BACKGROUND & AIMS: The immunoinhibitory receptor programmed death 1 (PD-1) is up-
regulated on dysfunctional virus-specific CD8 T cells during chronic viral infections, and …
regulated on dysfunctional virus-specific CD8 T cells during chronic viral infections, and …