Molecular and immunological mechanisms of clonal evolution in multiple myeloma
Multiple myeloma (MM) is a hematologic malignancy characterized by the proliferation of
clonal plasma cells in the bone marrow (BM). It is known that early genetic mutations in post …
clonal plasma cells in the bone marrow (BM). It is known that early genetic mutations in post …
[HTML][HTML] CRL4CRBN E3 Ligase Complex as a Therapeutic Target in Multiple Myeloma
J Barankiewicz, A Salomon-Perzyński… - Cancers, 2022 - mdpi.com
Simple Summary Immunomodulatory drugs (IMiDs) are effective in the treatment of multiple
myeloma (MM) and other hematological malignancies. Cereblon (CRBN), a target of IMiDs …
myeloma (MM) and other hematological malignancies. Cereblon (CRBN), a target of IMiDs …
Liquid biopsy-based monitoring of residual disease in multiple myeloma by analysis of the rearranged immunoglobulin genes–A feasibility study
The need for sensitive monitoring of minimal/measurable residual disease (MRD) in multiple
myeloma emerged as novel therapies led to deeper responses. Moreover, the potential …
myeloma emerged as novel therapies led to deeper responses. Moreover, the potential …
[HTML][HTML] A systematic literature review on clonal evolution events preceding relapse in multiple myeloma
Despite considerable treatment advances, multiple myeloma (MM) remains an incurable
hematological cancer due to treatment resistance. A systematic literature search was …
hematological cancer due to treatment resistance. A systematic literature search was …
[HTML][HTML] Advancements in Multiple Myeloma Research: High-Throughput Sequencing Technologies, Omics, and the Role of Artificial Intelligence
A Gutiérrez-González, I Del Hierro… - Biology, 2024 - mdpi.com
Multiple myeloma is a complex and challenging type of blood cancer that affects plasma
cells in the bone marrow. In recent years, the development of advanced research …
cells in the bone marrow. In recent years, the development of advanced research …
Mutations of ARID1B, PIK3C2B, KMT2B, and FAT1 genes influence clinical outcome in newly diagnosed myeloma
M Morawska, M Kiełbus, M Paziewska, M Szelest… - Cancer Genetics, 2024 - Elsevier
The study aimed to elucidate the mutational profile of patients with newly diagnosed multiple
myeloma to understand correlations of alterations with clinical outcomes. A cohort of 20 …
myeloma to understand correlations of alterations with clinical outcomes. A cohort of 20 …