Non-alcoholic fatty liver disease (NAFLD), currently the leading cause of global chronic liver
disease, has emerged as a major public health problem, more efficient therapeutics of which …

Recent advances have greatly improved our understanding of the molecular mechanisms
behind atherosclerosis pathogenesis. However, there is still a need to systematize this data …

Caloric restriction (CR) prolongs life span, yet the mechanisms by which it does so remain
poorly understood. Under CR, mice self-impose chronic cycles of 2-hour feeding and 22 …

How intestinal microbes regulate metabolic syndrome is incompletely understood. We show
that intestinal microbiota protects against development of obesity, metabolic syndrome, and …

Understanding the mechanisms underlying how T cells become dysfunctional in a tumor
microenvironment (TME) will greatly benefit cancer immunotherapy. We found that …

Macrophages are a heterogeneous population of immune cells playing several and diverse
functions in homeostatic and immune responses. The broad spectrum of macrophage …

Non-alcoholic fatty liver disease (NAFLD) is currently the world's most common liver
disease, estimated to affect up to one-fourth of the population. Hallmarked by hepatic …

Long-chain fatty acids (FAs) are components of plasma membranes and an efficient fuel
source and also serve as metabolic regulators through FA signaling mediated by membrane …

Fatty acids (FAs) are essential nutrients, but how they are transported into cells remains
unclear. Here, we show that FAs trigger caveolae-dependent CD36 internalization, which in …

Metazoan tissue specification is associated with integration of macrophage lineage cells in
sub-tissular niches to promote tissue development and homeostasis. Oncogenic …