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Pathogenesis of HIV-1 and Mycobacterium tuberculosis co-infection
Co-infection with Mycobacterium tuberculosis is the leading cause of death in individuals
infected with HIV-1. It has long been known that HIV-1 infection alters the course of M …
infected with HIV-1. It has long been known that HIV-1 infection alters the course of M …
Pathophysiology of CD4+ T-cell depletion in HIV-1 and HIV-2 infections
The hall mark of human immunodeficiency virus (HIV) infection is a gradual loss of CD4+ T-
cells and imbalance in CD4+ T-cell homeostasis, with progressive impairment of immunity …
cells and imbalance in CD4+ T-cell homeostasis, with progressive impairment of immunity …
Systemic effects of inflammation on health during chronic HIV infection
Combination antiretroviral therapy for HIV infection improves immune function and
eliminates the risk of AIDS-related complications but does not restore full health. HIV …
eliminates the risk of AIDS-related complications but does not restore full health. HIV …
The activation of bystander CD8+ T cells and their roles in viral infection
During viral infections, significant numbers of T cells are activated in a T cell receptor-
independent and cytokine-dependent manner, a phenomenon referred to as “bystander …
independent and cytokine-dependent manner, a phenomenon referred to as “bystander …
CD4+ T‐cell depletion in HIV infection: mechanisms of immunological failure
The hallmark of acquired immunodeficiency syndrome (AIDS) pathogenesis is a progressive
depletion of CD 4+ T‐cell populations in close association with progressive impairment of …
depletion of CD 4+ T‐cell populations in close association with progressive impairment of …
Tuberculosis and HIV coinfection
J Bruchfeld, M Correia-Neves… - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
Tuberculosis (TB) and human immunodeficiency virus/acquired immunodeficiency
syndrome (HIV/AIDS) constitute the main burden of infectious disease in resource-limited …
syndrome (HIV/AIDS) constitute the main burden of infectious disease in resource-limited …
Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism
Progressive HIV infection is characterized by dysregulation of the intestinal immune barrier,
translocation of immunostimulatory microbial products, and chronic systemic inflammation …
translocation of immunostimulatory microbial products, and chronic systemic inflammation …
HIV infection
More than 75 million people worldwide have been infected with human immunodeficiency
virus (HIV), and there are now approximately 37 million individuals living with the infection …
virus (HIV), and there are now approximately 37 million individuals living with the infection …
Nonhuman primate models of human viral infections
Humans have a close phylogenetic relationship with nonhuman primates (NHPs) and share
many physiological parallels, such as highly similar immune systems, with them. Importantly …
many physiological parallels, such as highly similar immune systems, with them. Importantly …
Plasma levels of soluble CD14 independently predict mortality in HIV infection
Background. Chronic human immunodeficiency virus (HIV) infection is associated with
intestinal permeability and microbial translocation that contributes to systemic immune …
intestinal permeability and microbial translocation that contributes to systemic immune …