Toxicities of opioid analgesics: respiratory depression, histamine release, hemodynamic changes, hypersensitivity, serotonin toxicity

BA Baldo - Archives of toxicology, 2021 - Springer
Opioid-induced respiratory depression is potentially life-threatening and often regarded as
the main hazard of opioid use. Main cause of death is cardiorespiratory arrest with hypoxia …

The serotonin syndrome: from molecular mechanisms to clinical practice

J Francescangeli, K Karamchandani, M Powell… - International journal of …, 2019 - mdpi.com
The serotonin syndrome is a medication-induced condition resulting from serotonergic
hyperactivity, usually involving antidepressant medications. As the number of patients …

The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity

EJC Dunkley, GK Isbister, D Sibbritt, AH Dawson… - Qjm, 2003 - academic.oup.com
Background: There are difficulties with the diagnosis of serotonin toxicity, particularly with
the use of Sternbach's criteria. Aim: To improve the criteria for diagnosing clinically …

Serotonin syndrome: a brief review

P Birmes, D Coppin, L Schmitt, D Lauque - Cmaj, 2003 - cmaj.ca
Une version française de cet article est disponible sur le site www. jamc. ca elevated
transaminase levels or lower bicarbonate levels have been reported. 2, 3, 8 Disseminated …

Opioid analgesic drugs and serotonin toxicity (syndrome): mechanisms, animal models, and links to clinical effects

BA Baldo - Archives of toxicology, 2018 - Springer
Drugs may cause serotonin toxicity by a number of different mechanisms including inhibition
of serotonin uptake and metabolism, increased serotonin synthesis and release, activation …

[책][B] Drug-induced diseases: prevention, detection, and management

JE Tisdale, DA Miller - 2010 - books.google.com
According to the authors, a drug-induced disease as an unintended effect of a drug, which
results in mortality or morbidity with symptoms sufficient to prompt a patient to seek medical …

[PDF][PDF] Serotonin toxicity: a practical approach to diagnosis and treatment

GK Isbister, NA Buckley, IM Whyte - Medical Journal of Australia, 2007 - mja.com.au
Excess serotonin in the central nervous system leads to a condition commonly referred to as
the serotonin syndrome, but better described as a spectrum of toxicity—serotonin toxicity.• …

The serotonin toxidrome: shortfalls of current diagnostic criteria for related syndromes

AL Chiew, NA Buckley - Clinical Toxicology, 2022 - Taylor & Francis
Introduction Serotonin syndrome (toxicity) describes adverse drug effects from toxic amounts
of intra-synaptic central nervous system serotonin. A wide range of drugs have been …

The pathophysiology of serotonin toxicity in animals and humans: implications for diagnosis and treatment

GK Isbister, NA Buckley - Clinical neuropharmacology, 2005 - journals.lww.com
Serotonin toxicity (or serotonin syndrome) has become an increasingly common and
important clinical problem in medicine over the last 15 years with the introduction of many …

Conundrums in neurology: diagnosing serotonin syndrome–a meta-analysis of cases

U Werneke, F Jamshidi, DM Taylor, M Ott - BMC neurology, 2016 - Springer
Background Serotonin syndrome is a toxic state, caused by serotonin (5HT) excess in the
central nervous system. Serotonin syndrome's main feature is neuro-muscular …