Strategies to address key challenges of metallacycle/metallacage-based supramolecular coordination complexes in biomedical applications

D Xu, Y Li, S Yin, F Huang - Chemical Society Reviews, 2024 - pubs.rsc.org
Owing to their capacity for dynamically linking two or more functional molecules,
supramolecular coordination complexes (SCCs), exemplified by two-dimensional (2D) …

Protein assembly by design

J Zhu, N Avakyan, A Kakkis, AM Hoffnagle… - Chemical …, 2021 - ACS Publications
Proteins are nature's primary building blocks for the construction of sophisticated molecular
machines and dynamic materials, ranging from protein complexes such as photosystem II …

Transition-metal coordinate bonds for bioinspired macromolecules with tunable mechanical properties

E Khare, N Holten-Andersen, MJ Buehler - Nature Reviews Materials, 2021 - nature.com
Transition-metal coordination complexes are emerging as a broad class of supramolecular
crosslinks that can be used to engineer the mechanical properties of advanced structural …

Recent advances of self-assembling peptide-based hydrogels for biomedical applications

J Li, R **ng, S Bai, X Yan - Soft matter, 2019 - pubs.rsc.org
Peptide-based hydrogels have been proven to be preeminent biomedical materials due to
their high water content, tunable mechanical stability, great biocompatibility and excellent …

Self‐assembled peptide‐and protein‐based nanomaterials for antitumor photodynamic and photothermal therapy

M Abbas, Q Zou, S Li, X Yan - Advanced materials, 2017 - Wiley Online Library
Tremendous interest in self‐assembly of peptides and proteins towards functional
nanomaterials has been inspired by naturally evolving self‐assembly in biological …

Chiral protein supraparticles for tumor suppression and synergistic immunotherapy: an enabling strategy for bioactive supramolecular chirality construction

J Yan, Y Yao, S Yan, R Gao, W Lu, W He - Nano letters, 2020 - ACS Publications
The design of bioactive supramolecular chirality is always hampered by the lack of feasible
schemes to assigned specific biological activities. Herein, we developed a “mirror-image …

Accurate design of megadalton-scale two-component icosahedral protein complexes

JB Bale, S Gonen, Y Liu, W Sheffler, D Ellis, C Thomas… - Science, 2016 - science.org
Nature provides many examples of self-and co-assembling protein-based molecular
machines, including icosahedral protein cages that serve as scaffolds, enzymes, and …

Supramolecular polymers in aqueous media

E Krieg, MMC Bastings, P Besenius… - Chemical …, 2016 - ACS Publications
This review discusses one-dimensional supramolecular polymers that form in aqueous
media. First, naturally occurring supramolecular polymers are described, in particular …

Protein assembly: versatile approaches to construct highly ordered nanostructures

Q Luo, C Hou, Y Bai, R Wang, J Liu - Chemical Reviews, 2016 - ACS Publications
Nature endows life with a wide variety of sophisticated, synergistic, and highly functional
protein assemblies. Following Nature's inspiration to assemble protein building blocks into …

De novo protein design, a retrospective

IV Korendovych, WF DeGrado - Quarterly reviews of biophysics, 2020 - cambridge.org
Proteins are molecular machines whose function depends on their ability to achieve
complex folds with precisely defined structural and dynamic properties. The rational design …