In vitro and computational investigations of novel synthetic carboxamide-linked pyridopyrrolopyrimidines with potent activity as SARS-CoV-2-M Pro inhibitors
An essential target for COVID-19 is the main protease of SARS-CoV-2 (Mpro). With the
objective of targeting this receptor, a novel set of pyrido [1, 2-a] pyrrolo [2, 3-d] pyrimidines …
objective of targeting this receptor, a novel set of pyrido [1, 2-a] pyrrolo [2, 3-d] pyrimidines …
A review on multipurpose potential of bioactive heterocycle quinoxaline
In last few decades, nitrogen‐containing heterocycles have maintained their status as an
important core of FDA‐approved drugs and medicinally active compounds. Quinoxaline is …
important core of FDA‐approved drugs and medicinally active compounds. Quinoxaline is …
Robust antiviral activity of commonly prescribed antidepressants against emerging coronaviruses: in vitro and in silico drug repurposing studies
During the current coronavirus disease 2019 (COVID-19) pandemic, symptoms of
depression are commonly documented among both symptomatic and asymptomatic …
depression are commonly documented among both symptomatic and asymptomatic …
Apoptosis induction, PARP-1 inhibition, and cell cycle analysis of leukemia cancer cells treated with novel synthetic 1, 2, 3-triazole-chalcone conjugates
Leukemia is a life-threatening nonepithelial malignant disorder that is characterized by
uncontrolled growth of the hematopoietic cells. To date, there are still unmet needs for …
uncontrolled growth of the hematopoietic cells. To date, there are still unmet needs for …
From triazolophthalazines to triazoloquinazolines: A bioisosterism-guided approach toward the identification of novel PCAF inhibitors with potential anticancer activity
Inhibition of PCAF bromodomain has been validated as a promising strategy for the
treatment of cancer. In this study, we report the bioisosteric modification of the first reported …
treatment of cancer. In this study, we report the bioisosteric modification of the first reported …
The antimicrobial potential and pharmacokinetic profiles of novel quinoline-based scaffolds: synthesis and in silico mechanistic studies as dual DNA gyrase and …
MH El-Shershaby, KM El-Gamal, AH Bayoumi… - New Journal of …, 2021 - pubs.rsc.org
The resistance of pathogenic microbes to currently available antimicrobial agents has been
considered a global alarming concern. Hence, close attention should be paid to the …
considered a global alarming concern. Hence, close attention should be paid to the …
Pharmacophore‐linked pyrazolo[3,4‐d]pyrimidines as EGFR‐TK inhibitors: Synthesis, anticancer evaluation, pharmacokinetics, and in silico mechanistic studies
Targeting the epidermal growth factor receptors (EGFRs) with small inhibitor molecules has
been validated as a potential therapeutic strategy in cancer therapy. Pyrazolo [3, 4‐d] …
been validated as a potential therapeutic strategy in cancer therapy. Pyrazolo [3, 4‐d] …
[HTML][HTML] An insight into the therapeutic impact of quinoxaline derivatives: Recent advances in biological activities (2020–2024)
AM Waseem, RM Elmagzoub, MMM Abdelgadir… - Results in …, 2024 - Elsevier
Quinoxaline derivatives have garnered significant attention due to their wide-ranging
therapeutic applications. Research from 2020 to 2024 has demonstrated their potent …
therapeutic applications. Research from 2020 to 2024 has demonstrated their potent …
The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, in vitro, and in silico …
Abstract Treatment options for the management of breast cancer are still inadequate. This
inadequacy is attributed to the lack of effective targeted medications, often resulting in the …
inadequacy is attributed to the lack of effective targeted medications, often resulting in the …
Rationale design, synthesis, cytotoxicity evaluation, and in silico mechanistic studies of novel 1, 2, 3-triazoles with potential anticancer activity
A new set of 1, 2, 3-triazoles was designed and synthesized to evaluate their potential to
inhibit the growth of cancer cells. Thiazole, thiazolone, and hydrazine as effective fragments …
inhibit the growth of cancer cells. Thiazole, thiazolone, and hydrazine as effective fragments …