Lynch syndrome, which is now recognized as the most common hereditary colorectal cancer
condition, is characterized by the predisposition to a spectrum of cancers, primarily …

Colorectal cancer (CRC) is the third most common diagnosed malignancy among both
sexes in the United States as well as in the European Union. While the incidence and …

DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role
in maintaining genomic stability. The specificity of MMR is primarily for base-base …

By removing biosynthetic errors from newly synthesized DNA, mismatch repair (MMR)
improves the fidelity of DNA replication by several orders of magnitude. Loss of MMR brings …

In∼ 30% of families affected by colorectal adenomatous polyposis, no germline mutations
have been identified in the previously implicated genes APC, MUTYH, POLE, POLD1, and …

The mismatch repair gene MSH3 has been implicated as a genetic modifier of the CAG·
CTG repeat expansion disorders Huntington's disease and myotonic dystrophy type 1. A …

Organisms have developed several DNA‐repair pathways as well as DNA‐damage
checkpoints to cope with the frequent challenge of endogenous and exogenous DNA …

The genetic basis of sporadic colorectal cancer has illuminated our knowledge of human
cancer genetics. This has been facilitated and catalyzed by an appreciation and deep …

DNA mismatch repair (MMR) proteins are ubiquitous players in a diverse array of important
cellular functions. In its role in post-replication repair, MMR safeguards the genome …

Decreasing oocyte competence with maternal aging is a major factor in human infertility. To
investigate the age-dependent molecular changes in a mouse model, we compared the …