The thymus is the primary lymphoid organ supplying new lymphocytes to the periphery.
Clinical and morphologic studies of HIV-infected children and adults indicate that the thymus …

Despite thymic involution, the number of naive CD4+ T cells diminishes slowly during aging,
suggesting considerable peripheral homeostatic expansion of these cells. To investigate the …

Recent advances in characterizing thymic function confirm the importance of thymus to T-cell
diversity in the periphery of both children and adults during both health and disease. Lack of …

Objectives We have analyzed the parameters (bacterial translocation, immune activation
and regulation, presence of HCV coinfection) which could be implicated in an inappropriate …

We studied the influence of AIDS restriction genes (ARGs) CCR5-Δ32, CCR2-64I, SDF1-3′
A, IL10-5′ A, CX 3 CR1-V249I, CX 3 CR1-T280M, and MDR1-C3435T and haplotypes of …

Background: Poor CD4 lymphocyte recovery on antiretroviral therapy (ART) is associated
with reduced function of the thymus. Palifermin (keratinocyte growth factor), by providing …

Current models hold that CD4+ depletion occurs as a result of direct and indirect effects of
HIV, which both kill peripheral CD4+ cells and prevent adequate regeneration. Although age …

Objectives To examine risk factors for sub‐optimal CD4 recovery on suppressive highly
active antiretroviral therapy (HAART) and assess long‐term clinical and immunological …

An optimal control approach based on an enlarged nonlinear model for the dynamics of HIV
infection and thymic function is composed to simulate and evaluate antiretroviral therapies …

This study provides the mathematical model of the interaction between the HIV and CD4+ T
cells. This research develops other research by formulating a model with the fractional …