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[HTML][HTML] Molecular and clinical aspects of potential neurotoxicity induced by new psychoactive stimulants and psychedelics
New psychoactive stimulants and psychedelics continue to play an important role on the
illicit new psychoactive substance (NPS) market. Designer stimulants and psychedelics both …
illicit new psychoactive substance (NPS) market. Designer stimulants and psychedelics both …
Reinstatement of synaptic plasticity in the aging brain through specific dopamine transporter inhibition
J Lubec, P Kalaba, AM Hussein, DD Feyissa, MH Kotob… - 2021 - nature.com
Aging-related neurological deficits negatively impact mental health, productivity, and social
interactions leading to a pronounced socioeconomic burden. Since declining brain …
interactions leading to a pronounced socioeconomic burden. Since declining brain …
The interaction of organic cation transporters 1-3 and PMAT with psychoactive substances
Abstract Organic cation transporters 1-3 (OCT1-3, SLC22A1-3) and the plasma membrane
monoamine transporter (PMAT, SLC29A4) play a major role in maintaining monoaminergic …
monoamine transporter (PMAT, SLC29A4) play a major role in maintaining monoaminergic …
Differentiated HT22 cells as a novel model for in vitro screening of serotonin reuptake inhibitors
J Lim, Y Bang, KM Kim, HJ Choi - Frontiers in Pharmacology, 2023 - frontiersin.org
The mouse hippocampal neuronal cell line HT22 is frequently used as an in vitro model to
investigate the role of hippocampal cholinergic neurons in cognitive functions. HT22 cells …
investigate the role of hippocampal cholinergic neurons in cognitive functions. HT22 cells …
[HTML][HTML] α-PPP and its derivatives are selective partial releasers at the human norepinephrine transporter: a pharmacological characterization of interactions between …
While classical cathinones, such as methcathinone, have been shown to be monoamine
releasing agents at human monoamine transporters, the subgroup of α-pyrrolidinophenones …
releasing agents at human monoamine transporters, the subgroup of α-pyrrolidinophenones …
Pharmacological characterization of toludesvenlafaxine as a triple reuptake inhibitor
H Zhu, W Wang, C Sha, W Guo, C Li, F Zhao… - Frontiers in …, 2021 - frontiersin.org
Toludesvenlafaxine hydrochloride dihydrate is a novel chemical entity and a potential triple
monoamine reuptake inhibitor. This study characterized the in vitro triple reuptake inhibition …
monoamine reuptake inhibitor. This study characterized the in vitro triple reuptake inhibition …
Bioisosteric analogs of MDMA: Improving the pharmacological profile?
Methylenedioxymethamphetamine (MDMA,'ecstasy') is re‐emerging in clinical settings as a
candidate for the treatment of specific neuropsychiatric disorders (eg post‐traumatic stress …
candidate for the treatment of specific neuropsychiatric disorders (eg post‐traumatic stress …
Characterization of neurotransmitter inhibition for seven cathinones by a proprietary fluorescent dye method
Many new psychoactive substances (NPS) are stimulants, and information about their
potency and abuse potential is often lacking. To start addressing this need, a method …
potency and abuse potential is often lacking. To start addressing this need, a method …
Interaction profiles of central nervous system active drugs at human organic cation transporters 1–3 and human plasma membrane monoamine transporter
Many psychoactive compounds have been shown to primarily interact with high-affinity and
low-capacity solute carrier 6 (SLC6) monoamine transporters for norepinephrine (NET; …
low-capacity solute carrier 6 (SLC6) monoamine transporters for norepinephrine (NET; …
Effects of Hydroxylated Mephedrone Metabolites on Monoamine Transporter Activity in vitro
Mephedrone is a largely abused psychostimulant. It elicits the release of monoamines via
the high affinity transporters for dopamine (DAT), norepinephrine (NET) and serotonin …
the high affinity transporters for dopamine (DAT), norepinephrine (NET) and serotonin …