Our genomes influence nearly every aspect of human biology—from molecular and cellular
functions to phenotypes in health and disease. Studying the differences in DNA sequence …

Target discovery is one of the essential steps in modern drug development, and the
identification of promising targets is fundamental for develo** first-in-class drug. A variety …

Geroscience puts mechanisms of aging as a driver of the most common age-related
diseases and dysfunctions. Under this perspective, addressing the basic mechanisms of …

Background Despite well‐recognized differences in the atherosclerotic cardiovascular
disease risk between men and women, sex differences in risk factors and sex‐specific …

Long non-coding RNAs (lncRNAs) are known to perform important regulatory functions in
lipid metabolism. Large-scale whole-genome sequencing (WGS) studies and new statistical …

Background The relationship between mitochondrial DNA copy number (mtDNA CN) and
cardiovascular disease remains elusive. Methods and Results We performed cross …

Adenosine triphosphate-binding cassette transporter subfamily A member 7 (ABCA7) is a
major risk factor for Alzheimer's disease. Human neural cell lines were used to investigate …

Cardiovascular diseases (CVD) are the leading cause of death worldwide for both men and
women, but their prevalence and burden show marked sex differences. The existing …

Animal survival depends on cognitive abilities such as learning and memory to adapt to
environmental changes. Memory functions require an enhanced activity and connectivity of …

Observational studies showed that metabolic phenotypes were associated with the risk of
develo** breast cancer (BC). However, those results are inconsistent regarding the …