Periodic segmentation of vertebrate embryos or somitogenesis is regulated by a dynamic
network of signalling pathways. Signalling gradients determine the spacing of the forming …

Adipose tissue is conventionally recognized as a metabolic organ responsible for storing
energy. However, a proportion of adipose tissue also functions as a thermogenic organ …

The distinct anatomic environment in which adipose tissues arise during organogenesis is a
principle determinant of their adult expansion capacity. Metabolic disease results from a …

The cellular complexity of the endochondral bone underlies its essential and pleiotropic
roles during organismal life. While the adult bone has received significant attention, we still …

Sympathetic innervation of brown adipose tissue (BAT) controls mammalian adaptative
thermogenesis. However, the cellular and molecular underpinnings contributing to BAT …

Brown adipose tissue (BAT) is responsible for non-shivering thermogenesis, but it is absent
in some mammals, including pigs. During development, BAT progenitors are derived from …

In mammals, brown adipose tissue (BAT) and beige adipocytes in white adipose tissue
(WAT) play pivotal roles in maintaining body temperature and energy metabolism. In mice …

Motivation Mitochondria are essential for cellular metabolism and are inherently flexible to
allow correct function in a wide range of tissues. Consequently, dysregulated mitochondrial …

Elongation of the posterior body axis is driven by multi-potent neuromesodermal progenitors
(NMPs), which both self-renew and simultaneously generate neural tube, neural crest, and …

Brown adipose tissue is responsible for non-shivering thermogenesis, controlling
temperature regulation in newborns and childhood, and then in adults under cold …