Oxidative stress reflects an imbalance between the overproduction and incorporation of free
radicals and the dynamic ability of a biosystem to detoxify reactive intermediates. Free …

The aggregation of alpha-synuclein (α-Syn) plays a critical role in the development of
Parkinson's disease (PD) and other synucleinopathies. α-Syn, which is encoded by the …

Objective The pathogenesis of Parkinson's disease (PD) involves complex interactions
between environmental and genetic factors. Metabolomics can shed light on alterations in …

Parkinson disease is caused by neuronal loss in the substantia nigra which manifests by
abnormality of movement, muscle tone, and postural stability. Several genes have been …

Increases in S-nitrosylation and inactivation of the neuroprotective ubiquitin E3 ligase,
parkin, in the brains of patients with Parkinson's disease are thought to be pathogenic and …

Loss-of-function mutations in the PINK1 or parkin genes result in recessive heritable forms of
parkinsonism. Genetic studies of Drosophila orthologs of PINK1 and parkin indicate that …

Parkinson's disease (PD) is histologically described by the deposition of α-synuclein, whose
accumulation in Lewy bodies causes dopaminergic neuronal death. Although most of PD …

Abstract Cysteine-persulfide (Cys-SSH) is a cysteine whose sulfhydryl group is covalently
bound to sulfur (sulfane sulfur). Cys-SSH and its glutathione (GSH) counterpart (GSSH) …

Cockayne syndrome (CS) is a devastating autosomal recessive disease characterized by
neurodegeneration, cachexia, and accelerated aging. 80% of the cases are caused by …

Mitochondria are essential organelles for neuronal function and cell survival. Besides the
well-known bioenergetics, additional mitochondrial roles in calcium signaling, lipid …