Genetics of substance use disorders in the era of big data
Substance use disorders (SUDs) are conditions in which the use of legal or illegal
substances, such as nicotine, alcohol or opioids, results in clinical and functional …
substances, such as nicotine, alcohol or opioids, results in clinical and functional …
[HTML][HTML] Genetics of type 2 diabetes
Since early 2007, the establishment of international consortia and biobanks has catalyzed
the performance of large-scale genomic studies. These efforts have driven an explosion in …
the performance of large-scale genomic studies. These efforts have driven an explosion in …
Rare variant contribution to the heritability of coronary artery disease
Whole genome sequences (WGS) enable discovery of rare variants which may contribute to
missing heritability of coronary artery disease (CAD). To measure their contribution, we …
missing heritability of coronary artery disease (CAD). To measure their contribution, we …
Association of SLC11A1 polymorphisms with anthropometric and biochemical parameters describing Type 2 Diabetes Mellitus
Diabetes, a leading cause of death globally, has different types, with Type 2 Diabetes
Mellitus (T2DM) being the most prevalent one. It has been established that variations in the …
Mellitus (T2DM) being the most prevalent one. It has been established that variations in the …
Unravelling the genetic architecture of human complex traits through whole genome sequencing
Whole genome sequencing has enabled new insights into the genetic architecture of
complex traits, especially through access to low-frequency and rare variation. This Comment …
complex traits, especially through access to low-frequency and rare variation. This Comment …
Challenge accepted: uncovering the role of rare genetic variants in Alzheimer's disease
The search for rare variants in Alzheimer's disease (AD) is usually deemed a high-risk-high-
reward situation. The challenges associated with this endeavor are real. Still, the application …
reward situation. The challenges associated with this endeavor are real. Still, the application …
Integration of evidence across human and model organism studies: A meeting report
Abstract The National Institute on Drug Abuse and Joint Institute for Biological Sciences at
the Oak Ridge National Laboratory hosted a meeting attended by a diverse group of …
the Oak Ridge National Laboratory hosted a meeting attended by a diverse group of …
Whole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification
Coronary artery calcification (CAC) is a measure of atherosclerosis and a well-established
predictor of coronary artery disease (CAD) events. Here we describe a genome-wide …
predictor of coronary artery disease (CAD) events. Here we describe a genome-wide …
Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program
D DiCorpo, SM Gaynor, EM Russell… - Communications …, 2022 - nature.com
The genetic determinants of fasting glucose (FG) and fasting insulin (FI) have been studied
mostly through genome arrays, resulting in over 100 associated variants. We extended this …
mostly through genome arrays, resulting in over 100 associated variants. We extended this …
Шкалы для оценки генетического риска развития сахарного диабета 2-го типа
ОВ Курилова, АВ Киселева, АН Мешков… - Профилактическая …, 2021 - elibrary.ru
Сахарный диабет 2-го типа (СД2) является независимым фактором риска сердечно-
сосудистых заболеваний, наличие которых значимо повышает сердечно-сосудистый …
сосудистых заболеваний, наличие которых значимо повышает сердечно-сосудистый …