The SARS-coronavirus infection cycle: a survey of viral membrane proteins, their functional interactions and pathogenesis
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a novel epidemic
strain of Betacoronavirus that is responsible for the current viral pandemic, coronavirus …
strain of Betacoronavirus that is responsible for the current viral pandemic, coronavirus …
Research in the field of drug design and development
G Biala, E Kedzierska, M Kruk-Slomka… - Pharmaceuticals, 2023 - mdpi.com
The processes used by academic and industrial scientists to discover new drugs have
recently experienced a true renaissance, with many new and exciting techniques being …
recently experienced a true renaissance, with many new and exciting techniques being …
[HTML][HTML] Structural elucidation of SARS-CoV-2 vital proteins: Computational methods reveal potential drug candidates against main protease, Nsp12 polymerase and …
Recently emerged SARS-CoV-2 caused a major outbreak of coronavirus disease 2019
(COVID-19) and instigated a widespread fear, threatening global health safety. To date, no …
(COVID-19) and instigated a widespread fear, threatening global health safety. To date, no …
[HTML][HTML] Promising terpenes as SARS-CoV-2 spike receptor-binding domain (RBD) attachment inhibitors to the human ACE2 receptor: Integrated computational …
The spike protein receptor binding domain (S-RBD) is a necessary corona-viral protein for
binding and entry of coronaviruses (COVs) into the host cells. Hence, it has emerged as an …
binding and entry of coronaviruses (COVs) into the host cells. Hence, it has emerged as an …
Pharmacoinformatics and molecular dynamics simulation studies reveal potential covalent and FDA-approved inhibitors of SARS-CoV-2 main protease 3CLpro
The SARS-CoV-2 was confirmed to cause the global pandemic of coronavirus disease 2019
(COVID-19). The 3-chymotrypsin-like protease (3CLpro), an essential enzyme for viral …
(COVID-19). The 3-chymotrypsin-like protease (3CLpro), an essential enzyme for viral …
[HTML][HTML] Discovery of human coronaviruses pan-papain-like protease inhibitors using computational approaches
The papain-like protease (PL pro) is vital for the replication of coronaviruses (CoVs), as well
as for esca** innate-immune responses of the host. Hence, it has emerged as an …
as for esca** innate-immune responses of the host. Hence, it has emerged as an …
Drug repurposing: A strategy for discovering inhibitors against emerging viral infections
IJ dos Santos Nascimento… - Current Medicinal …, 2021 - ingentaconnect.com
Background: Viral diseases are responsible for several deaths around the world. Over the
past few years, the world has seen several outbreaks caused by viral diseases that, for a …
past few years, the world has seen several outbreaks caused by viral diseases that, for a …
In Vitro Antidiabetic, Anti-Obesity and Antioxidant Analysis of Ocimum basilicum Aerial Biomass and in Silico Molecular Docking Simulations with Alpha-Amylase and …
The present study explored phytochemicals, porcine pancreatic α-amylase (PPA) and lipase
(PPL) inhibitory activities and antioxidant potential of polar and nonpolar extracts of the …
(PPL) inhibitory activities and antioxidant potential of polar and nonpolar extracts of the …
Discovery of Rift Valley fever virus natural pan-inhibitors by targeting its multiple key proteins through computational approaches
Abstract The Rift Valley fever virus (RVFV) is a zoonotic arbovirus and pathogenic to both
humans and animals. Currently, no proven effective RVFV drugs or licensed vaccine are …
humans and animals. Currently, no proven effective RVFV drugs or licensed vaccine are …
Discovery of anti-MERS-CoV small covalent inhibitors through pharmacophore modeling, covalent docking and molecular dynamics simulation
Middle east respiratory syndrome coronavirus (MERS-CoV) is a fatal pathogen that poses a
serious health risk worldwide and especially in the middle east countries. Targeting the …
serious health risk worldwide and especially in the middle east countries. Targeting the …