Since 1955, several alkyl‐carbamates have been developed for the treatment of anxiety and
epilepsy, including meprobamate, flupirtine, felbamate, retigabine, carisbamate, and …

The rising interest in Kv7 modulators originates from their ability to evoke fundamental
electrophysiological perturbations in a tissue-specific manner. A large number of therapeutic …

Among the five KCNQ channels, also known as the K v 7 voltage-gated potassium (K v)
channels, KCNQ2–KCNQ5 control neuronal excitability. Dysfunctions of KCNQ2–KCNQ5 …

We previously reported that P-retigabine (P-RTG), a retigabine (RTG) analogue bearing a
propargyl group at the nitrogen atom in the linker of RTG, displayed moderate …

Native M-current is a low-threshold, slowly activating potassium current that exerts an
inhibitory control over neuronal excitability. The M-channel is primarily co-assembled by …

The central nervous system, information integration center of the body, is mainly composed
of neurons and glial cells. The neuron is one of the most basic and important structural and …

The potassium channel opening drugs flupirtine and retigabine have been withdrawn from
the market due to occasional drug-induced liver injury (DILI) and tissue discoloration …

Kv7 K+ channels represent attractive pharmacological targets for the treatment of different
neurological disorders, including epilepsy. In this paper, 42 conformationally restricted …

Trigeminal inflammatory pain is one of the most severe pain-related disorders in humans;
however, the underlying mechanisms remain largely unknown. In this study, we investigated …

The KV7 potassium channel openers flupirtine and retigabine have been valuable options in
the therapy of pain and epilepsy. However, as a result of adverse reactions, both drugs are …