Neutrophils or polymorphonuclear leukocytes (PMN) are key participants in the innate
immune response for their ability to execute different effector functions. These cells express …

Polymorphonuclear leukocytes (PMNs) are the most abundant white cell in humans and an
essential component of the innate immune system. PMNs are typically the first type of …

Mitochondria are known to combine life-supporting functions with participation in apoptosis
by controlling caspase activity. Here, we report that in human blood neutrophils the …

Apoptosis is coordinated by members of the caspase family of aspartic acid-specific
proteases. Other members of this protease family also play essential roles in inflammation …

Pyroptosis is a proinflammatory mode of lytic cell death mediated by accumulation of plasma
membrane (PM) macropores composed of gasdermin‐family (GSDM) proteins. It facilitates …

The innate immune system is the first line of host defense against invading microorganisms.
Polymorphonuclear leukocytes (PMNs or neutrophils) are the most abundant leukocyte in …

Alpha-herpesvirus causes lifelong infections and serious diseases in a wide range of hosts
and has developed multiple strategies to counteract the host defense. Here, we demonstrate …

Analyses of neutrophil death mechanisms have revealed many similarities with other cell
types; however, a few important molecular features make these cells unique executors of …

Human neutrophilic granulocytes form the largest pool of innate immune cells for host
defense against bacterial and fungal pathogens. The dynamic changes that accompany the …

Neutrophil constitutive death is a critical cellular process for modulating neutrophil number
and function, and it plays an essential role in neutrophil homeostasis and the resolution of …