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Chagas disease: Immunology of the disease at a glance
Chagas disease is an important neglected disease that affects 6–7 million people
worldwide. The disease has two phases: acute and chronic, in which there are different …
worldwide. The disease has two phases: acute and chronic, in which there are different …
Cytokine networks as targets for preventing and controlling Chagas heart disease
Chagas disease, a neglected disease caused by the protozoan Trypanosoma cruzi, is
endemic in 21 Latin American countries, affecting 6–8 million people. Increasing numbers of …
endemic in 21 Latin American countries, affecting 6–8 million people. Increasing numbers of …
Disease Tolerance and Pathogen Resistance Genes May Underlie Trypanosoma cruzi Persistence and Differential Progression to Chagas Disease Cardiomyopathy
Chagas disease is caused by infection with the protozoan Trypanosoma cruzi and affects
over 8 million people worldwide. In spite of a powerful innate and adaptive immune …
over 8 million people worldwide. In spite of a powerful innate and adaptive immune …
Pathogenesis of chronic Chagas disease: macrophages, mitochondria, and oxidative stress
Abstract Purpose of Review Trypanosoma cruzi is the causative agent of Chagas disease.
Decades after initial infection,~ 30% of individuals can develop chronic chagasic …
Decades after initial infection,~ 30% of individuals can develop chronic chagasic …
CCR5 and CCR5Δ32 in bacterial and parasitic infections: Thinking chemokine receptors outside the HIV box
The CCR5 molecule was reported in 1996 as the main HIV‐1 co‐receptor. In that same year,
the CCR5Δ32 genetic variant was described as a strong protective factor against HIV‐1 …
the CCR5Δ32 genetic variant was described as a strong protective factor against HIV‐1 …
Differential expression profile of genes involved in the immune response associated to progression of chronic Chagas disease
I Gómez, MC López, A Egui, G Palacios… - PLOS Neglected …, 2023 - journals.plos.org
Background Patients with chronic Chagas disease present marked clinical and
immunological heterogeneity. During the disease, multiple immune mechanisms are …
immunological heterogeneity. During the disease, multiple immune mechanisms are …
[HTML][HTML] Genomic medicine in Chagas disease
Genetic approaches have been proposed for improving the understanding of the causes of
differential susceptibility to Trypanosoma cruzi infection and Chagas disease outcome …
differential susceptibility to Trypanosoma cruzi infection and Chagas disease outcome …
CCR5Δ32 in Brazil: Impacts of a European genetic variant on a highly admixed population
The genetic background of Brazilians encompasses Amerindian, African, and European
components as a result of the colonization of an already Amerindian inhabited region by …
components as a result of the colonization of an already Amerindian inhabited region by …
Determination of the Th1, Th2, Th17, and Treg cytokine profile in patients with chronic Chagas heart disease and systemic arterial hypertension
Chronic Chagas heart disease (CCHD affects about 30% of patients with chronic Chagas
disease (CCD). Systemic arterial hypertension (SAH) afflicts about 25% of patients with …
disease (CCD). Systemic arterial hypertension (SAH) afflicts about 25% of patients with …
Increased frequencies of circulating CCR5+ memory T cells are correlated to chronic chagasic cardiomyopathy progression
The infection with the protozoan parasite Trypanosoma cruzi causes Chagas disease, a
neglected tropical disease in Latin America and an imported emerging disease worldwide …
neglected tropical disease in Latin America and an imported emerging disease worldwide …