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Chromatin accessibility: biological functions, molecular mechanisms and therapeutic application
Y Chen, R Liang, Y Li, L Jiang, D Ma, Q Luo… - Signal Transduction and …, 2024 - nature.com
The dynamic regulation of chromatin accessibility is one of the prominent characteristics of
eukaryotic genome. The inaccessible regions are mainly located in heterochromatin, which …
eukaryotic genome. The inaccessible regions are mainly located in heterochromatin, which …
[HTML][HTML] LSD1 Regulates Neurogenesis in Human Neural Stem Cells Through the Repression of Human-Enriched Extracellular Matrix and Cell Adhesion Genes
AS Channakkar, L D'Souza, A Kumar, K Kalia… - Stem Cells, 2024 - academic.oup.com
Neurogenesis begins with neural stem cells undergoing symmetric proliferative divisions to
expand and then switching to asymmetric differentiative divisions to generate neurons in the …
expand and then switching to asymmetric differentiative divisions to generate neurons in the …
Modeling Cortical Versus Hippocampal Network Dysfunction in a Human Brain Assembloid Model of Epilepsy and Intellectual Disability
Neurodevelopmental disorders often impair multiple cognitive domains. For instance, a
genetic epilepsy syndrome might cause seizures due to cortical hyperexcitability and …
genetic epilepsy syndrome might cause seizures due to cortical hyperexcitability and …
Analysis of downstream targets of PAX6 and LHX2, fundamental regulators of the develo** mammalian neocortex
The transcription factors PAX6 and LHX2 play fundamental roles in mammalian cerebral
cortical development. Loss of either factor causes depletion of the cortical progenitor pool …
cortical development. Loss of either factor causes depletion of the cortical progenitor pool …