Constituent isoflavones of Puerariae radix as a potential neuroprotector in cognitive impairment: evidence from preclinical studies

Y Ren, S Qu - Ageing research reviews, 2023 - Elsevier
With the increasing aging population worldwide, the incidence of senile cognitive
impairment (CI) is increasing, posing a serious threat to the health of elderly persons …

(Ascorb) ing Pb neurotoxicity in the develo** brain

F Ahmad, P Liu - Antioxidants, 2020 - mdpi.com
Lead (Pb) neurotoxicity is a major concern, particularly in children. Developmental exposure
to Pb can alter neurodevelopmental trajectory and has permanent neuropathological …

[HTML][HTML] Proteome signatures of joint toxicity to arsenic (As) and lead (Pb) in human brain organoids with optic vesicles

S Chen, A Abdulla, H Yan, Q Mi, X Ding, J He… - Environmental …, 2024 - Elsevier
Abstract Arsenic (As) and lead (Pb) are toxins found in the natural surroundings, and the
harmful health outcomes caused by the co-exposure of such toxins have become a …

Prenatal lead exposure, telomere length in cord blood, and DNA methylation age in the PROGRESS prenatal cohort

JF Herrera-Moreno, G Estrada-Gutierrez, H Wu… - Environmental …, 2022 - Elsevier
Background Lead is a ubiquitous pollutant with deleterious effects on human health and
remains a major current public health concern in develo** countries. This heavy metal …

Relevance of biometals during neuronal differentiation and myelination: in vitro and in vivo studies

M Chin-Chan, S Montes, VM Blanco-Álvarez… - BioMetals, 2022 - Springer
Biometals are essential during the development of the central nervous system (CNS) since
they participate in the organization and regulation of multiple processes related with the …

The potential role of nanoyttria in alleviating oxidative stress biomarkers: Implications for Alzheimer's disease therapy

K San Tang - Life sciences, 2020 - Elsevier
Alzheimer's disease (AD) is a fatal neurodegenerative disease that requires immediate
attention. Oxidative stress that leads to the generation of reactive oxygen species is a …

Chronic Pb exposure impairs learning and memory abilities by inhibiting excitatory projection neuro-circuit of the hippocampus in mice

RX Zou, X Gu, C Huang, HL Wang, X Chen - Toxicology, 2024 - Elsevier
Lead (Pb) is an environmental neurotoxic metal. Chronic Pb exposure causes behavioral
changes in humans and rodents, such as dysfunctional learning and memory. Nevertheless …

Epigenetics and environmental health

M Zhang, T Hu, T Ma, W Huang, Y Wang - Frontiers of Medicine, 2024 - Springer
Epigenetic modifications including DNA methylation, histone modifications, chromatin
remodeling, and RNA modifications complicate gene regulation and heredity and profoundly …

[PDF][PDF] REVIEW OF RECENT EVIDENCE FROM MECHANISTIC STUDIES

MSR Giasuddin Ahmed, E Perez, KM Khan - 2025 - preprints.org
Numerous epidemiological studies indicate that populations exposed to environmental
hazards such as heavy metals have a higher likelihood of develo** Alzheimer's disease …

Epigenetics and lead neurotoxicity

Y Xu, T Wang, J Zhang - Lead Chemistry, 2020 - books.google.com
Lead exposure continues to threaten human health in a worldwide perspective. Among the
multiple target organs affected by lead, central nervous system (CNS) pervades in the …