The poor predictability of human liver toxicity is still causing high attrition rates of drug
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …

The development of novel antiretroviral treatments has led to a significant turning point in the
fight against HIV. Although therapy leads to virologic suppression and prolonged life …

Ovarian cancer is the second most common gynaecologic malignancy and the main cause
of death from gynaecologic cancer, due to late diagnosis and chemoresistance. Studies …

In this review encouraged by original data, we first provided in vivo evidence that the kidney,
comparative to the liver or brain, is an organ particularly rich in cysteine. In the kidney, the …

Ovarian cancer is the main cause of death from gynecological cancer, with its poor
prognosis mainly related to late diagnosis and chemoresistance (acquired or intrinsic) to …

Highly active antiretroviral treatment has led to unprecedented efficacy and tolerability in
people living with HIV. This effect was also observed in the central nervous system with the …

Combination antiretroviral therapy (cART) dramatically changed the face of the HIV/AIDS
pandemic, making it one of the most prominent medical breakthroughs of the past 3 …

Long-term cognitive dysfunction, or “chemobrain”, has been observed in cancer patients
treated with chemotherapy. Mitoxantrone (MTX) is a topoisomerase II inhibitor that binds and …

The activation of endothelial cells (ECs) is a crucial step on the road map of tumor
angiogenesis and expanding evidence indicates that a pro-oxidant tumor microenvironment …

Scope Diets rich in (poly) phenols have been associated with positive effects on
neurodegenerative disorders, such as Parkinson's disease (PD). Several low‐molecular …