Neural respiratory drive, ie, the activity of respiratory centres controlling breathing, is an
overlooked physiologic variable which affects the pathophysiology and the clinical outcome …

Breathing's remarkable ability to adapt to changes in metabolic, environmental, and
behavioral demands stems from a complex integration of its rhythm-generating network …

The analgesic utility of opioid-based drugs is limited by the life-threatening risk of respiratory
depression. Opioid-induced respiratory depression (OIRD), mediated by the μ-opioid …

The ability of neuronal networks to reconfigure is a key property underlying behavioral
flexibility. Networks with recurrent topology are particularly prone to reconfiguration through …

Breathing in mammals relies on permanent rhythmic and bilaterally synchronized
contractions of inspiratory pump muscles. These motor drives emerge from interactions …

Sighs prevent the collapse of alveoli in the lungs, initiate arousal under hypoxic conditions,
and are an expression of sadness and relief. Sighs are periodically superimposed on …

How might synaptic dynamics generate synchronous oscillations in neuronal networks? We
address this question in the preBötzinger complex (preBötC), a brainstem neural network …

Death from opioid overdose is typically caused by opioid-induced respiratory depression
(OIRD). A particularly dangerous characteristic of OIRD is its apparent unpredictability. The …

Aging and disease are accompanied with a reduction of complex variability in the temporal
patterns of heart rate. This reduction has been attributed to a break down of the underlying …

The rhythm generating network for breathing must continuously adjust to changing
metabolic and behavioral demands. Here, we examined network-based mechanisms in the …