Cell cycle control in cancer

HK Matthews, C Bertoli, RAM de Bruin - Nature reviews Molecular cell …, 2022 - nature.com
Cancer is a group of diseases in which cells divide continuously and excessively. Cell
division is tightly regulated by multiple evolutionarily conserved cell cycle control …

How multiscale curvature couples forces to cellular functions

M Luciano, C Tomba, A Roux, S Gabriele - Nature Reviews Physics, 2024 - nature.com
Among the physicochemical cues in the cellular microenvironment that orchestrate cell
processes, the different levels of curvature in the extracellular matrix and intrinsic to the …

Embryo mechanics cartography: inference of 3D force atlases from fluorescence microscopy

S Ichbiah, F Delbary, A McDougall, R Dumollard… - Nature …, 2023 - nature.com
Tissue morphogenesis results from a tight interplay between gene expression, biochemical
signaling and mechanics. Although sequencing methods allow the generation of cell …

Cell size homeostasis is tightly controlled throughout the cell cycle

X Liu, J Yan, MW Kirschner - PLoS biology, 2024 - journals.plos.org
To achieve a stable size distribution over multiple generations, proliferating cells require a
means of counteracting stochastic noise in the rate of growth, the time spent in various …

Intracellular softening and increased viscoelastic fluidity during division

S Hurst, BE Vos, M Brandt, T Betz - Nature Physics, 2021 - nature.com
The life and death of an organism rely on correct cell division, which occurs through the
process of mitosis. Although the biochemical signalling and morphogenetic processes …

Aberrant cortex contractions impact mammalian oocyte quality

E Nikalayevich, G Letort, G de Labbey, E Todisco… - Developmental Cell, 2024 - cell.com
The cortex controls cell shape. In mouse oocytes, the cortex thickens in an Arp2/3-complex-
dependent manner, ensuring chromosome positioning and segregation. Surprisingly, we …

Mechanical regulation of cell-cycle progression and division

VK Gupta, O Chaudhuri - Trends in cell biology, 2022 - cell.com
Cell-cycle progression and division are fundamental biological processes in animal cells,
and their biochemical regulation has been extensively studied. An emerging body of work …

Three-dimensional structure of kinetochore-fibers in human mitotic spindles

R Kiewisz, G Fabig, W Conway, D Baum, D Needleman… - Elife, 2022 - elifesciences.org
During cell division, kinetochore microtubules (KMTs) provide a physical linkage between
the chromosomes and the rest of the spindle. KMTs in mammalian cells are organized into …

[HTML][HTML] Cell cycle control by cell-matrix interactions

MJ Jones, MC Jones - Current Opinion in Cell Biology, 2024 - Elsevier
Cell adhesion to the extracellular matrix (ECM) is required for normal cell cycle progression
and accurate cell division. However, how cell adhesion to the wide range of ECM proteins …

Protein and lipid mass concentration measurement in tissues by stimulated Raman scattering microscopy

S Oh, CH Lee, W Yang, A Li, A Mukherjee… - Proceedings of the …, 2022 - pnas.org
Cell mass and chemical composition are important aggregate cellular properties that are
especially relevant to physiological processes, such as growth control and tissue …