Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

S Xu, I Ilyas, J Weng - Acta Pharmacologica Sinica, 2023 - nature.com
The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is
still raging. However, the pathophysiology of acute and post-acute manifestations of COVID …

Aging, immunity, and COVID-19: how age influences the host immune response to coronavirus infections?

V Bajaj, N Gadi, AP Spihlman, SC Wu, CH Choi… - Frontiers in …, 2021 - frontiersin.org
The novel coronavirus severe acute respiratory syndrome coronavirus 2 causing the
Coronavirus disease (COVID-19) pandemic has ravaged the world with over 72 million total …

CD209L/L-SIGN and CD209/DC-SIGN act as receptors for SARS-CoV-2

R Amraei, W Yin, MA Napoleon, EL Suder… - ACS Central …, 2021 - ACS Publications
As the COVID-19 pandemic continues to spread, investigating the processes underlying the
interactions between SARS-CoV-2 and its hosts is of high importance. Here, we report the …

Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells

R Amraei, C **a, J Olejnik, MR White… - Proceedings of the …, 2022 - National Acad Sciences
SARS-CoV-2 entry into host cells is a crucial step for virus tropism, transmission, and
pathogenesis. Angiotensin-converting enzyme 2 (ACE2) has been identified as the primary …

Vaccine-induced COVID-19 mimicry syndrome

E Kowarz, L Krutzke, M Külp, P Streb, P Larghero… - Elife, 2022 - elifesciences.org
To fight the Covid-19 pandemic caused by the RNA virus SARS-CoV-2 a global vaccination
campaign is in progress to achieve the immunization of billions of people mainly with …

Endothelial damage in acute respiratory distress syndrome

AG Vassiliou, A Kotanidou, I Dimopoulou… - International journal of …, 2020 - mdpi.com
The pulmonary endothelium is a metabolically active continuous monolayer of squamous
endothelial cells that internally lines blood vessels and mediates key processes involved in …

Of mice and men: the coronavirus MHV and mouse models as a translational approach to understand SARS-CoV-2

RW Koerner, M Majjouti, MAA Alcazar, E Mahabir - Viruses, 2020 - mdpi.com
The fatal acute respiratory coronavirus disease 2019 (COVID-19) is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Since COVID-19 was declared a …

Endothelial Dysfunction, Inflammation, and Oxidative Stress in COVID‐19—Mechanisms and Therapeutic Targets

A Fodor, B Tiperciuc, C Login… - Oxidative medicine …, 2021 - Wiley Online Library
The outbreak of the COVID‐19 pandemic represents an ongoing healthcare emergency
responsible for more than 3.4 million deaths worldwide. COVID‐19 is the disease caused by …

Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies

X Wu, M Xu, M Geng, S Chen, PJ Little, S Xu… - Signal transduction and …, 2023 - nature.com
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …

The role of NO in COVID-19 and potential therapeutic strategies

W Fang, J Jiang, L Su, T Shu, H Liu, S Lai… - Free radical biology and …, 2021 - Elsevier
Nitric oxide (NO) is a free radical playing an important pathophysiological role in
cardiovascular and immune systems. Recent studies reported that NO levels were …