C-reactive protein (CRP) is routinely assessed as a marker of systemic inflammation in
rheumatoid arthritis (RA). However, it is also an immune regulator that plays an important …

Macrophages and neutrophils are key components involved in the regulation of numerous
chronic inflammatory diseases, infectious disorders, and especially certain autoimmune …

Objective To develop evidence-based European Alliance of Associations for Rheumatology
(EULAR) points to consider (PtCs) for the management of difficult-to-treat rheumatoid …

Objectives: The goal of this study was to assess the diffuse myocardial fibrosis and edema in
rheumatoid arthritis (RA) using multiparametric cardiac magnetic resonance (CMR) and the …

Synovial macrophages are one of the resident cell types in synovial tissue and while they
remain relatively quiescent in the healthy joint, they become activated in the inflamed joint …

Interleukin-6 (IL-6) is a pleiotropic cytokine involved in the regulation of the cross talk
between haematopoietic/immune cells and stromal cells, including the onset and resolution …

Objective Quantitative assessment of disease activity in rheumatoid arthritis (RA) is
important for patient management, and additional objective information may aid …

Tumor necrosis factor (TNF)-α is a pleiotropic cytokine implicated in the etiology of several
autoimmune diseases, including rheumatoid arthritis (RA). TNF-α regulates diverse effector …

Disturbed expression of microRNAs (miRNAs) in regulatory T cells (Tregs) leads to
development of autoimmunity in experimental mouse models. However, the miRNA …

Background Autoimmune diseases such as rheumatoid arthritis (RA) are the consequence
of a persistent imbalance between pro-and anti-inflammatory immune mechanisms, leading …