T cells are critically important for host defense against infections. T cell activation is specific
because signal initiation requires T cell receptor (TCR) recognition of foreign antigen …

Cell–cell interfaces are found throughout multicellular organisms, from transient interactions
between motile immune cells to long-lived cell–cell contacts in epithelia. Studies of immune …

Morphological transitions are typically attributed to the actions of proteins and lipids. Largely
overlooked in membrane shape regulation is the glycocalyx, a pericellular membrane coat …

Cells mediate interactions with the extracellular environment through a crowded assembly of
transmembrane proteins, glycoproteins and glycolipids on their plasma membrane. The …

Cells run on initiation of protein-protein interactions, which are dynamically tuned spatially
and temporally to modulate cellular events. This tuning can be physical, such as attaching …

The spatial organization of cell membrane glycoproteins and glycolipids is critical for
mediating the binding of ligands, receptors, and macromolecules on the plasma membrane …

Glucose is an important energy source in our bodies, and its consumption results in
gradients over length scales ranging from the subcellular to entire organs. Concentration …

Through the magic of “active matter”─ matter that converts chemical energy into mechanical
work to drive emergent properties─ biology solves a myriad of seemingly enormous …

Molecular and structural facets of cell–cell adhesion have been extensively studied in
monolayered epithelia. Here, we perform a comprehensive analysis of cell–cell contacts in a …

Due to the enhanced labeling capability of maleimide-based fluorescent probes, lysine-
cysteine-lysine (KCK) tags are frequently added to proteins for visualization. In this study, we …