Mutational dynamics of SARS-CoV-2: Impact on future COVID-19 vaccine strategies

N Faraji, T Zeinali, F Joukar, MS Aleali, N Eslami… - Heliyon, 2024 - cell.com
The rapid emergence of multiple strains of Severe Acute Respiratory Syndrome Coronavirus-
2 (SARS-CoV-2) has sparked profound concerns regarding the ongoing evolution of the …

SARS-coV-2 membrane protein regulates the function of spike by inhibiting its plasma membrane localization and enzymatic activity of furin

Q **ang, J Wu, Y Zhou, L Li, M Tian, G Li, Z Zhang… - Microbiological …, 2024 - Elsevier
The presence of a multibasic cleavage site in the Spike protein of SARS-CoV-2 makes it
prone to be cleaved by Furin at the S1/S2 junction (aa. 685–686), which enhances the …

CD81 fusion alters SARS-CoV-2 Spike trafficking

AS Cone, Y Zhou, RP McNamara, AB Eason, GF Arias… - Mbio, 2024 - journals.asm.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic caused the
biggest public health crises in recent history. Many expect future coronavirus introductions …

[HTML][HTML] Strengths and limitations of SARS-CoV-2 virus-like particle systems

R Sultana, RV Stahelin - Virology, 2024 - Elsevier
Virus-like particles (VLPs) resemble the parent virus but lack the viral genome, providing a
safe and efficient platform for the analysis of virus assembly and budding as well as the …

Inhibition of protein kinase D and its substrate phosphatidylinositol-4 kinase III beta blocks common human coronavirus replication

H Han, H Liu, R Steiner, Z Zhao, ZG ** - Microbiology Spectrum, 2024 - journals.asm.org
ABSTRACT Coronavirus disease 2019 (COVID-19) is caused by the infection of a
coronavirus, named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Application of machine learning algorithms to identify serological predictors of COVID-19 severity and outcomes

S Dhakal, A Yin, M Escarra-Senmarti… - Communications …, 2024 - nature.com
Background Critically ill hospitalized patients with COVID-19 have greater antibody titers
than those with mild to moderate illness, but their association with recovery or death from …

Self-aligning nanojunctions for integrated single-molecule circuits

B Liu, B Demir, CA Gultakti, J Marrs, Y Gong, R Li… - ACS …, 2024 - ACS Publications
Robust, high-yield integration of nanoscale components such as graphene nanoribbons,
nanoparticles, or single-molecules with conventional electronic circuits has proven to be …

A Bayesian Assessment of the Origins of COVID-19 using Spatiotemporal and Zoonotic Data

AT Levin - 2025 - nber.org
This paper uses Bayesian methods in conjunction with spatiotemporal and zoonotic data to
evaluate the odds ratio for two hypotheses regarding the origin of the COVID-19 pandemic …

Sequential Glycosylations at the Multibasic Cleavage Site of SARS-CoV-2 Spike Protein Regulate Viral Activation, Assembly, and Infection

S Wang, W Ran, L Sun, Q Fan, Y Zhao, B Wang… - 2023 - researchsquare.com
The multibasic furin cleavage site at the S1/S2 boundary of the spike protein (S protein) is a
hallmark of SARS-CoV-2 and is essential for its increased infectivity. O-glycosylation near …

Antigen-display exosomes provide adjuvant-free protection against SARS-CoV-2 disease at nanogram levels of spike protein

C Guo, J Sachithanandham, W Zhong, M Craney… - …, 2024 - pmc.ncbi.nlm.nih.gov
As the only bionormal nanovesicle, exosomes have high potential as a nanovesicle for
delivering vaccines and therapeutics. We show here that the loading of type-1 membrane …