Neuronal action potentials or spikes provide a long-range, noise-resistant means of
communication between neurons. As point processes single spikes contain little information …

A major problem in developmental neurotoxicity (DNT) risk assessment is the lack of
toxicological hazard information for most compounds. Therefore, new approaches are being …

Multiple non-animal-based test methods have never been formally validated. In order to use
such new approach methods (NAMs) in a regulatory context, criteria to define their …

Reciprocal copy number variations (CNVs) of 16p11. 2 are associated with a wide spectrum
of neuropsychiatric and neurodevelopmental disorders. Here, we use human induced …

Drug-induced seizure liabilities produce significant compound attrition during drug
discovery. Currently available in vitro cytotoxicity assays cannot predict all toxicity …

Brain extracellular matrix (ECM) is often overlooked in vitro brain tissue models, despite its
instructive roles during development. Using developmental stage-sourced brain ECM in …

Astrocytes and neurons respond to each other by releasing transmitters, such as γ-
aminobutyric acid (GABA) and glutamate, that modulate the synaptic transmission and …

Accurate identification of bursting activity is an essential element in the characterization of
neuronal network activity. Despite this, no one technique for identifying bursts in spike trains …

The electrophysiological technology having a high spatiotemporal resolution at the single‐
cell level and noninvasive measurements of large areas provide insights on underlying …

Bursts of action potentials within neurons and throughout networks are believed to serve
roles in how neurons handle and store information, both in vivo and in vitro. Accurate …