Physical activity and depression: Towards understanding the antidepressant mechanisms of physical activity

A Kandola, G Ashdown-Franks, J Hendrikse… - Neuroscience & …, 2019 - Elsevier
Physical activity can treat and prevent depressive symptoms, but its antidepressant
mechanisms are yet to be established. In this review, we comprehensively assess key …

Bridging animal and human models of exercise-induced brain plasticity

MW Voss, C Vivar, AF Kramer, H van Praag - Trends in cognitive sciences, 2013 - cell.com
Significant progress has been made in understanding the neurobiological mechanisms
through which exercise protects and restores the brain. In this feature review, we integrate …

Exercise is the real polypill

C Fiuza-Luces, N Garatachea, NA Berger… - Physiology, 2013 - journals.physiology.org
The concept of a “polypill” is receiving growing attention to prevent cardiovascular disease.
Yet similar if not overall higher benefits are achievable with regular exercise, a drug-free …

BDNF mediates adaptive brain and body responses to energetic challenges

K Marosi, MP Mattson - Trends in Endocrinology & Metabolism, 2014 - cell.com
Emerging findings suggest that brain-derived neurotrophic factor (BDNF) serves widespread
roles in regulating energy homeostasis by controlling patterns of feeding and physical …

[HTML][HTML] Towards a psychobiotic therapy for depression: Bifidobacterium breve CCFM1025 reverses chronic stress-induced depressive symptoms and gut microbial …

P Tian, KJ O'Riordan, Y Lee, G Wang, J Zhao… - Neurobiology of …, 2020 - Elsevier
Background Accumulating evidence points to an association between gut microbial
abnormalities and depression disorder. The microbiota-gut-brain axis is an emerging target …

Running-induced systemic cathepsin B secretion is associated with memory function

HY Moon, A Becke, D Berron, B Becker, N Sah… - Cell metabolism, 2016 - cell.com
Peripheral processes that mediate beneficial effects of exercise on the brain remain sparsely
explored. Here, we show that a muscle secretory factor, cathepsin B (CTSB) protein, is …

Roles of myokines in exercise-induced improvement of neuropsychiatric function

S Kim, JY Choi, S Moon, DH Park, HB Kwak… - … -European Journal of …, 2019 - Springer
Exercise is a well-known non-pharmacological intervention to improve brain functions,
including cognition, memory, and motor coordination. Contraction of skeletal muscles during …

BDNF isoforms: a round trip ticket between neurogenesis and serotonin?

RB Foltran, SL Diaz - Journal of neurochemistry, 2016 - Wiley Online Library
The brain‐derived neurotrophic factor, BDNF, was discovered more than 30 years ago and,
like other members of the neurotrophin family, this neuropeptide is synthetized as a …

Aerobic exercise as a tool to improve hippocampal plasticity and function in humans: practical implications for mental health treatment

A Kandola, J Hendrikse, PJ Lucassen… - Frontiers in human …, 2016 - frontiersin.org
Aerobic exercise (AE) has been widely praised for its potential benefits to cognition and
overall brain and mental health. In particular, AE has a potent impact on promoting the …

Lifelong brain health is a lifelong challenge: from evolutionary principles to empirical evidence

MP Mattson - Ageing research reviews, 2015 - Elsevier
Although the human brain is exceptional in size and information processing capabilities, it is
similar to other mammals with regard to the factors that promote its optimal performance …