Molecular mechanisms of dietary restriction promoting health and longevity

CL Green, DW Lamming, L Fontana - Nature Reviews Molecular Cell …, 2022‏ - nature.com
Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

[HTML][HTML] A critical review of the evidence that metformin is a putative anti-aging drug that enhances healthspan and extends lifespan

I Mohammed, MD Hollenberg, H Ding… - Frontiers in …, 2021‏ - frontiersin.org
The numerous beneficial health outcomes associated with the use of metformin to treat
patients with type 2 diabetes (T2DM), together with data from pre-clinical studies in animals …

Vegetarian and vegan diets: benefits and drawbacks

T Wang, A Masedunskas, WC Willett… - European heart …, 2023‏ - academic.oup.com
Plant-based diets have become increasingly popular thanks to their purported health
benefits and more recently for their positive environmental impact. Prospective studies …

The ups and downs of caloric restriction and fasting: from molecular effects to clinical application

SJ Hofer, D Carmona‐Gutierrez, MI Mueller… - EMBO Molecular …, 2022‏ - embopress.org
Age‐associated diseases are rising to pandemic proportions, exposing the need for efficient
and low‐cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and …

[HTML][HTML] A Comprehensive Review of the Benefits of and the Barriers to the Switch to a Plant-Based Diet

A Fehér, M Gazdecki, M Véha, M Szakály, Z Szakály - Sustainability, 2020‏ - mdpi.com
In recent decades, the food industry has been faced with new challenges, and it has had to
develop new types of diets and produce new types of foods that can slow down the spread …

Impact of hypertension on cognitive function: a scientific statement from the American Heart Association

C Iadecola, K Yaffe, J Biller, LC Bratzke, FM Faraci… - …, 2016‏ - ahajournals.org
Background—Age-related dementia, most commonly caused by Alzheimer disease or
cerebrovascular factors (vascular dementia), is a major public health threat. Chronic arterial …

2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial

WE Kraus, M Bhapkar, KM Huffman… - The lancet Diabetes & …, 2019‏ - thelancet.com
Background For several cardiometabolic risk factors, values considered within normal range
are associated with an increased risk of cardiovascular morbidity and mortality. We aimed to …

Calorie restriction in humans: an update

J Most, V Tosti, LM Redman, L Fontana - Ageing research reviews, 2017‏ - Elsevier
Calorie restriction (CR), a nutritional intervention of reduced energy intake but with adequate
nutrition, has been shown to extend healthspan and lifespan in rodent and primate models …

Healthful aging mediated by inhibition of oxidative stress

SF Vatner, J Zhang, M Oydanich, T Berkman… - Ageing research …, 2020‏ - Elsevier
The progressive increase in lifespan over the past century carries with it some adversity
related to the accompanying burden of debilitating diseases prevalent in the older …

Sirtuins and type 2 diabetes: role in inflammation, oxidative stress, and mitochondrial function

M Kitada, Y Ogura, I Monno, D Koya - Frontiers in endocrinology, 2019‏ - frontiersin.org
The rising incidence of type 2 diabetes mellitus (T2DM) is a major public health concern,
and novel therapeutic strategies to prevent T2DM are urgently needed worldwide. Aging is …